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OSGIN1 Knockout Cell Lines

Gene: OSGIN1

Official Full Name: oxidative stress induced growth inhibitor 1provided by HGNC

Gene Summary: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26905 OSGIN1 Knockout cell line (HeLa) Human OSGIN1 1:3~1:6 Negative Online Inquiry
KO26906 OSGIN1 Knockout cell line (HCT 116) Human OSGIN1 1:2~1:4 Negative Online Inquiry
KO26907 OSGIN1 Knockout cell line (HEK293) Human OSGIN1 1:3~1:6 Negative Online Inquiry
KO26908 OSGIN1 Knockout cell line (A549) Human OSGIN1 1:3~1:4 Negative Online Inquiry

Background

OSGIN1 Gene Knockout Cell Lines are genetically modified cell lines featuring the knockout of the OSGIN1 gene, a gene implicated in cellular stress response and apoptosis regulation. By utilizing CRISPR-Cas9 technology, these cell lines exhibit a complete disruption of OSGIN1 function, enabling researchers to study its role in various biological processes, particularly in response to environmental stressors and their implications in diseases such as cancer and neurodegeneration.

The primary function of these knockout cell lines is to facilitate the investigation of the OSGIN1 gene's downstream effects on cellular signaling pathways and gene expression profiles. Through functional assays, researchers can observe alterations in cell viability, proliferation rates, and apoptotic markers that arise from the loss of OSGIN1 function. This mechanistic understanding is crucial for unraveling the complex biological networks that participate in stress response mechanisms and identifying potential targets for therapeutic intervention.

The scientific importance of OSGIN1 knockout cell lines extends to both fundamental research and clinical applications. They serve as valuable tools in drug discovery, providing a platform to evaluate the efficacy of novel compounds in modulating cellular stress pathways. Additionally, they can be instrumental in understanding the pathophysiology of stress-related diseases, offering insights that may lead to the development of targeted therapies.

What sets OSGIN1 Gene Knockout Cell Lines apart from alternative gene editing models is their specific targeting and validation for the OSGIN1 gene, which enhances their reliability and reproducibility in experimental settings. Additionally, the user-friendly nature of the cell lines, combined with robust phenotypic characterization and detailed documentation provided, significantly reduces the time and resources researchers would typically invest in creating their own genetically modified models.

By incorporating OSGIN1 Gene Knockout Cell Lines into their research toolbox, scientists and clinicians can accelerate their studies, leading to impactful discoveries in cancer biology, neuroprotection, and cell survival pathways. Our company, with its extensive experience in genetic engineering and a commitment to advancing biological research tools, provides the highest quality products and customer support to meet the needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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