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OR5H8 Knockout Cell Lines

Gene: OR5H8

Official Full Name: olfactory receptor family 5 subfamily H member 8 (gene/pseudogene)provided by HGNC

Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15480 OR5H8 Knockout cell line (HeLa) Human OR5H8 1:3~1:6 Negative Online Inquiry
KO15481 OR5H8 Knockout cell line (HCT 116) Human OR5H8 1:2~1:4 Negative Online Inquiry
KO15482 OR5H8 Knockout cell line (HEK293) Human OR5H8 1:3~1:6 Negative Online Inquiry
KO15483 OR5H8 Knockout cell line (A549) Human OR5H8 1:3~1:4 Negative Online Inquiry

Background

OR5H8 Gene Knockout Cell Lines are specifically engineered cellular models that have been developed to facilitate the study of the OR5H8 gene's functions and associated signaling pathways. Gene knockout techniques are pivotal in biological research as they enable scientists to systematically disrupt the expression of a specific gene, allowing for the direct observation of resultant phenotypic changes. These cell lines serve as an essential tool for functional genomics studies, enabling researchers to explore the role of the OR5H8 gene in various biological processes, including olfactory signaling and other receptor-related functions.

The primary mechanism of these knockout cell lines involves the use of CRISPR-Cas9 technology, allowing for precise and efficient disruption of the OR5H8 gene. By knocking out this gene, researchers can investigate downstream effects on cellular behavior, receptor interactions, and cellular responses to various stimuli. This detailed understanding of gene function is invaluable in deciphering complex biological networks and may contribute significantly to advancements in therapeutic strategies targeting olfactory dysfunction or associated sensory disorders.

The scientific importance of OR5H8 Gene Knockout Cell Lines extends to a wide range of applications in both research and clinical settings. They provide a robust platform for drug discovery, toxicology studies, and the investigation of receptor biology, thereby facilitating innovations in pharmacological research aimed at developing novel olfactory agents.

In comparison to traditional cell lines, OR5H8 knockout models offer unique advantages, such as enhanced specificity for gene function studies and a more precise experimental paradigm. Their ability to specifically eliminate the expression of the OR5H8 gene distinguishes them from other genetic models, providing researchers with a highly focused tool for their investigations.

For researchers and clinicians, the value of these knockout cell lines lies in their reliability and versatility. They represent a critical advancement in the field of genetics and molecular biology, empowering users to make significant contributions to scientific knowledge and therapeutic developments.

Our company prides itself on cutting-edge innovations in biological products, with a commitment to providing high-quality, reliable tools that facilitate groundbreaking research and clinical applications. The OR5H8 Gene Knockout Cell Lines exemplify our dedication to supporting the scientific community in unraveling the complexities of gene function.

Please note that all services are for research use only. Not intended for any clinical use.

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