Gene: OR51J1
Official Full Name: olfactory receptor family 51 subfamily J member 1provided by HGNC
Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15444 | OR51J1 Knockout cell line (HeLa) | Human | OR51J1 | 1:3~1:6 | Negative | Online Inquiry |
KO15445 | OR51J1 Knockout cell line (HCT 116) | Human | OR51J1 | 1:2~1:4 | Negative | Online Inquiry |
KO15446 | OR51J1 Knockout cell line (HEK293) | Human | OR51J1 | 1:3~1:6 | Negative | Online Inquiry |
KO15447 | OR51J1 Knockout cell line (A549) | Human | OR51J1 | 1:3~1:4 | Negative | Online Inquiry |
OR51J1 Gene Knockout Cell Lines represent a state-of-the-art tool in cellular and molecular biology, specifically designed for the in-depth study of olfactory receptor physiology and associated signaling pathways. These cell lines have been genetically engineered to express a disruption in the OR51J1 gene, facilitating scientists in exploring the functional role of this receptor in both normal and pathological states.
The primary mechanism involved in using OR51J1 Gene Knockout Cell Lines is the elimination of olfactory receptor signaling, which allows researchers to dissect the downstream effects of OR51J1 absence on cellular behavior and biochemical pathways. By utilizing these knockout models, scientists can investigate the implications of OR51J1 in various processes, including neuronal signaling, sensory perception, and the potential role in certain diseases such as cancer and neurodegenerative disorders.
The scientific importance of these cell lines is underscored by their pivotal role in translational research and drug discovery, particularly in understanding how olfactory receptors contribute to broader neurobiological functions. The utility of OR51J1 knockout models extends to therapeutic applications, allowing researchers to develop targeted interventions that modulate olfactory signaling in various clinical contexts.
Compared to traditional methods of gene editing or genetic silencing, the OR51J1 Gene Knockout Cell Lines offer unparalleled specificity and reproducibility. They eliminate potential off-target effects that could skew results, thus maintaining robust data integrity. Additionally, these cell lines provide a convenient platform for high-throughput screening of compounds that either activate or inhibit olfactory receptors, accelerating the pace of discovery in olfactory receptor research.
Given the growing interest in olfactory receptors and their far-reaching implications in both basic biological research and applied clinical therapy, OR51J1 Gene Knockout Cell Lines are an invaluable asset to the research community. They empower researchers and clinicians to make significant strides in understanding and manipulating olfactory signaling pathways.
Our company prides itself on its dedication to delivering high-quality biological products, and our expertise in genetic engineering enables us to support cutting-edge research with innovative solutions like the OR51J1 Gene Knockout Cell Lines. We are committed to advancing scientific inquiry and providing tools that drive impactful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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