Gene: OLR1
Official Full Name: oxidized low density lipoprotein receptor 1provided by HGNC
Gene Summary: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36261 | OLR1 Knockout cell line (HeLa) | Human | OLR1 | 1:3~1:6 | Negative | Online Inquiry |
KO36262 | OLR1 Knockout cell line (A549) | Human | OLR1 | 1:3~1:4 | Negative | Online Inquiry |
OLR1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the OLR1 gene, which encodes the oxidized low-density lipoprotein receptor 1. This product serves as a critical tool in research aimed at understanding the biological roles of OLR1 in lipid metabolism, inflammation, and cardiovascular diseases. By creating precise genetic deletions of the OLR1 gene, these cell lines enable scientists to dissect the functional impact of this receptor on cellular processes and signaling pathways.
The key functionality of OLR1 Gene Knockout Cell Lines lies in their ability to provide a controlled environment for studying the consequences of OLR1 absence. Researchers can utilize these knockout models to investigate processes such as cholesterol uptake, inflammatory responses, and the progression of atherosclerosis. The absence of OLR1 allows for the evaluation of compensatory mechanisms within lipid-related pathways, which can lead to significant insights into the development of therapeutic interventions targeting cardiovascular disorders.
In scientific research and clinical settings, OLR1 Gene Knockout Cell Lines are invaluable for elucidating the complex relationships between lipid metabolism and health conditions like atherosclerosis, obesity, and diabetes. These models offer a reliable platform for drug discovery, biomarker identification, and the assessment of novel therapeutic approaches designed to manage metabolic cardiovascular diseases.
What sets OLR1 Gene Knockout Cell Lines apart from alternative cell lines is their specificity and the reliability of the gene targeting techniques employed during their creation, ensuring a high degree of accuracy in genetic modification. Additionally, their compatibility with a wide range of experimental methods, including gene editing, reporter assays, and high-throughput screening, provides further confidence in experimentation.
For researchers and clinicians focused on cardiovascular health and metabolic research, OLR1 Gene Knockout Cell Lines represent a powerful asset. By facilitating a deeper understanding of OLR1’s functional role, they pave the way for advancements in therapeutic strategies aimed at combating cardiovascular diseases.
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Please note that all services are for research use only. Not intended for any clinical use.
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