Gene: OGT
Official Full Name: O-linked N-acetylglucosamine (GlcNAc) transferaseprovided by HGNC
Gene Summary: This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00353 | OGT gRNA1-gRNA2 KO plasmid | OGT | $850 | |||
KO00648 | OGT Knockout cell line(A549) | Human | OGT | 1:3~1:4 | Negative | Online Inquiry |
OGT Gene Knockout Cell Lines are precision-engineered cellular models that have been genetically modified to disrupt the expression of specific genes, providing invaluable tools for studying gene function and elucidating biological pathways. These cell lines are created using advanced gene-editing technologies, such as CRISPR/Cas9, which introduce targeted mutations or deletions to the genomic DNA. The resultant knockout cells enable researchers to investigate the role of individual genes in cellular processes, drug responses, and disease mechanisms.
The primary function of OGT Gene Knockout Cell Lines is to facilitate functional genomics studies by allowing for the isolation and characterization of gene-specific effects. By eliminating target gene expression, researchers can discern the contributions of these genes in various biological contexts, from cell signaling and metabolic pathways to differentiation and apoptosis. This comprehensive approach is critical for identifying potential therapeutic targets and understanding the genetic basis of diseases.
In research and clinical settings, OGT Gene Knockout Cell Lines hold significant scientific importance. Their applications extend from fundamental biology and pharmacology research to translational medicine, including cancer biology, neurobiology, and metabolic disorders. By utilizing these cell lines, scientists can develop better models of human disease, screen for drug candidates, and assess the efficacy of novel therapeutic strategies.
Compared to traditional knockdown or overexpression approaches, OGT Gene Knockout Cell Lines offer several advantages, including increased specificity of gene disruption, permanent changes in gene expression, and the potential to model homozygous mutations. Furthermore, the robustness and reliability of these cell lines significantly enhance reproducibility in experiments, facilitating more conclusive results.
For researchers and clinicians aiming to advance their understanding of genetic contributions to health and disease, OGT Gene Knockout Cell Lines represent a crucial resource. Their precise engineering and diverse applicability make them indispensable tools for pioneering discoveries. Our company prides itself on a commitment to quality and innovation, providing researchers with state-of-the-art genetic tools to accelerate their scientific endeavors effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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