Gene: OGFOD1
Official Full Name: 2-oxoglutarate and iron dependent oxygenase domain containing 1provided by HGNC
Gene Summary: Enables peptidyl-proline 3-dioxygenase activity. Involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Located in cytoplasmic stress granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15510 | OGFOD1 Knockout cell line (HeLa) | Human | OGFOD1 | 1:3~1:6 | Negative | Online Inquiry |
KO15511 | OGFOD1 Knockout cell line (HCT 116) | Human | OGFOD1 | 1:2~1:4 | Negative | Online Inquiry |
KO15512 | OGFOD1 Knockout cell line (HEK293) | Human | OGFOD1 | 1:3~1:6 | Negative | Online Inquiry |
KO15513 | OGFOD1 Knockout cell line (A549) | Human | OGFOD1 | 1:3~1:4 | Negative | Online Inquiry |
OGFOD1 Gene Knockout Cell Lines are genetically modified cellular models created by targeting and disrupting the OGFOD1 gene, which encodes for an essential protein involved in the regulation of post-translational modifications of histones. This innovative product serves as a pivotal tool for researchers studying gene function and regulation, particularly in the context of cancer, neurodegenerative diseases, and cellular senescence. The knockout of the OGFOD1 gene allows for the investigation of the gene's role in diverse biological processes and disease pathways, thus facilitating a deeper understanding of cellular mechanisms.
The primary mechanism of action of these knockout cell lines involves the complete loss of OGFOD1 protein expression, which is crucial in modulating the activity of various histone demethylases and thereby influencing gene expression. By utilizing these cell lines, researchers can elucidate the downstream effects of OGFOD1 deficiency, such as alterations in chromatin structure and transcriptional profiles, ultimately contributing to a clearer picture of its biological significance.
The scientific importance of OGFOD1 Gene Knockout Cell Lines extends to their applications in both research and clinical settings. They provide a platform for drug discovery, where potential therapeutic compounds can be screened for efficacy in reversing the phenotypic consequences of OGFOD1 knockout. Moreover, these cell lines can be pivotal in studying the mechanisms of resistance to therapies in cancer cell lines, thereby aiding in the development of combination treatment strategies.
One of the standout advantages of our OGFOD1 Gene Knockout Cell Lines is their high-quality, validated genetic modification, ensuring reliability and reproducibility in experimental results. Unlike conventional knockout methodologies, our offerings incorporate optimized editing techniques that yield precise gene disruption without off-target effects, maximizing experimental rigor. Additionally, our cell lines come with extensive documentation and support, simplifying the implementation for researchers.
For researchers and clinicians striving to advance their work in gene regulation and disease modeling, our OGFOD1 Gene Knockout Cell Lines represent an invaluable asset. By enabling a clearer understanding of complex biological mechanisms, they empower breakthroughs that can lead to innovative therapeutic strategies. As a leader in the field of biological products, our company is committed to providing high-quality, reliable tools that cater to the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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