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OFD1 Knockout Cell Lines

Gene: OFD1

Official Full Name: OFD1 centriole and centriolar satellite proteinprovided by HGNC

Gene Summary: This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome. [provided by RefSeq, Aug 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01023 OFD1 Knockout cell line (HEK293) Human OFD1 1:3~1:6 Negative Online Inquiry
KO34142 OFD1 Knockout cell line (HeLa) Human OFD1 1:3~1:6 Negative Online Inquiry
KO34143 OFD1 Knockout cell line (HCT 116) Human OFD1 1:2~1:4 Negative Online Inquiry
KO34144 OFD1 Knockout cell line (A549) Human OFD1 1:3~1:4 Negative Online Inquiry

Background

OFD1 Gene Knockout Cell Lines are advanced in vitro models generated through targeted gene editing techniques, specifically designed to study the biological functions and pathways associated with the OFD1 gene. OFD1, which is crucial for the proper structure and function of cilia, plays a significant role in the development and maintenance of various tissues. These knockout cell lines have been meticulously engineered to lack functional OFD1 protein, enabling researchers to investigate the physiological and pathological impacts of OFD1 deficiency.

The key functionality of OFD1 Gene Knockout Cell Lines lies in their ability to elucidate the molecular pathways that are disrupted upon OFD1 removal. By observing alterations in cellular processes such as ciliary assembly, signal transduction, and proliferation, scientists can gain deeper insights into diseases linked to OFD1, including Joubert Syndrome and other ciliopathies. This model facilitates targeted experimentation, allowing for the assessment of gene interactions and the screening of potential therapeutic compounds.

Moreover, the scientific importance of these cell lines extends into both research and clinical applications. They serve as a vital tool for understanding the mechanistic pathways of OFD1-related disorders and can be instrumental in preclinical drug testing, potential gene therapy approaches, and genetic studies. As precise models, they provide reproducibility and reliability in experimental outcomes, crucial for advancing translational research.

Compared to alternative cell lines, the OFD1 Gene Knockout variants stand out due to their specificity—not only do they remove OFD1 function, but their creation leverages CRISPR-Cas9 technology, ensuring high efficiency and fewer off-target effects. This specificity translates to high-quality data that can lead to more meaningful conclusions.

For researchers and clinicians seeking to unravel the complexities of ciliopathies and test innovative solutions, the OFD1 Gene Knockout Cell Lines offer unmatched value. Their utility in dissection of disease mechanisms equips users with the insights necessary for impactful discoveries.

Our company prides itself on its expertise in cellular models and gene editing technologies, ensuring that we provide cutting-edge products that meet the rigorous demands of both research and clinical environments. With a commitment to high-quality standards and customer satisfaction, we empower scientists to advance their research with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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