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Nlgn4l Knockout Cell Lines

Gene: Nlgn4l

Official Full Name: neuroligin 4-likeprovided by MGI

Gene Summary: Predicted to enable several functions, including chloride ion binding activity; neurexin family protein binding activity; and protein homodimerization activity. Involved in several processes, including brainstem development; social behavior; and territorial aggressive behavior. Located in plasma membrane and synapse. Is active in glycinergic synapse and postsynaptic specialization membrane. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN4X (neuroligin 4 X-linked) and NLGN4Y (neuroligin 4 Y-linked). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01247 Nlgn4l Knockout cell line (4T1) Mouse Nlgn4l 1:3~1:4 Negative Online Inquiry

Background

Nlgn4l Gene Knockout Cell Lines are highly specialized biological tools created through the precise elimination of the Nlgn4l gene, known for its significant role in synaptic development and functioning. These cell lines enable researchers to explore the intricate pathways and mechanisms underlying neuronal communication, making them pivotal for studies related to various neurodevelopmental disorders, including autism spectrum disorders and schizophrenia.

The primary function of Nlgn4l Gene Knockout Cell Lines is to facilitate the analysis of synaptic structure and function by providing a controlled environment in which the effects of Nlgn4l deficiency can be systematically evaluated. The loss of this gene alters cell signaling pathways and synaptic strength, thereby enabling researchers to investigate the molecular consequences of disrupted synaptic transmission. This mechanistic insight contributes to understanding how genetic mutations may lead to behavioral and cognitive dysfunctions in mammals.

From a scientific standpoint, these knockout cell lines are invaluable for both fundamental and applied research. In clinical settings, they can be leveraged to screen potential therapeutic agents targeting synaptic dysregulation, providing a platform for drug discovery and development. Furthermore, they can be employed in gene therapy studies, allowing researchers to assess the potential for restoring synaptic function through various treatment modalities.

Compared to alternative models, Nlgn4l Gene Knockout Cell Lines offer several unique advantages: they are easy to handle, genetically stable, and can be used in various cellular assays, including electrophysiological studies and high-throughput screening. Their specificity allows for higher reproducibility of results and better correlation with human conditions, making them superior to traditional animal models in certain contexts.

For researchers and clinicians focused on neurobiology and related fields, Nlgn4l Gene Knockout Cell Lines represent a cutting-edge resource that can accelerate the understanding of complex neurological processes and propel therapeutic advancements. Our company possesses deep expertise in gene editing technologies, ensuring that the quality and performance of our products meet the highest scientific standards. This commitment to excellence is reflected in our dedication to advancing research capabilities through innovative biological solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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