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NUPR2 Knockout Cell Lines

Gene: NUPR2

Official Full Name: nuclear protein 2, transcriptional regulatorprovided by HGNC

Gene Summary: Involved in several processes, including cellular response to starvation; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15566 NUPR2 Knockout cell line (HEK293) Human NUPR2 1:3~1:6 Negative Online Inquiry

Background

NUPR2 Gene Knockout Cell Lines are engineered cellular models that have undergone targeted genetic modification to disrupt the expression of the NUPR2 gene, a crucial regulator in various stress response pathways. This gene plays a significant role in cellular adaptation to oxidative stress and influences processes such as apoptosis and differentiation. By utilizing these knockout cell lines, researchers can study the contributions of NUPR2 in both normal physiology and pathological conditions, gaining insights into its role in cancer, neurodegenerative diseases, and other stress-related disorders.

The primary function of the NUPR2 Gene Knockout Cell Lines involves the elucidation of the gene's influence on cellular responses to stressors and its impacts on metabolic pathways. By observing the phenotypic and biochemical changes that occur in these knockout models, scientists can better understand the downstream signaling cascades that NUPR2 modulates. The precise mechanism enabling these observations relies upon the absence of NUPR2 protein, thereby allowing for the investigation of compensatory mechanisms and alternative pathways activated in the absence of typical NUPR2-mediated responses.

The scientific importance of these cell lines cannot be understated, particularly in research settings focused on cancer biology where NUPR2 is known to interact with numerous oncogenic pathways. In clinical applications, understanding the role of NUPR2 could lead to the development of targeted therapies that exploit its regulatory mechanisms. Additionally, these cell lines serve as valuable tools in drug discovery and toxicology assessments, offering a platform for investigating drug responses and side effects in a controlled environment.

Compared to alternative models, NUPR2 Gene Knockout Cell Lines offer distinct advantages, including a more precise investigation of NUPR2 function by eliminating confounding variables associated with partial gene silencing techniques. This results in clearer and more reproducible data. Furthermore, the knockout approach allows for longitudinal studies over time, yielding insights into cellular dynamics post-NUPR2 disruption.

For researchers and clinicians, the value of these knockout cell lines lies in their ability to generate meaningful data that could guide innovative therapeutic strategies. Whether exploring the complexities of cellular stress responses or assessing the therapeutic implications of NUPR2 activity, these cell lines bridge critical gaps in knowledge.

Our company specializes in providing high-quality biological products tailored to advance cutting-edge research. With an emphasis on precision and reproducibility, our NUPR2 Gene Knockout Cell Lines are designed to empower researchers in their quest for scientific discovery and clinical advances.

Please note that all services are for research use only. Not intended for any clinical use.

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