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NUMA1 Knockout Cell Lines

Gene: NUMA1

Official Full Name: nuclear mitotic apparatus protein 1provided by HGNC

Gene Summary: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00456 NUMA1 Knockout cell line (HEK293) Human NUMA1 1:3~1:6 Negative Online Inquiry
KO00457 NUMA1 Knockout cell line (A549) Human NUMA1 1:3~1:4 Negative Online Inquiry
KO36292 NUMA1 Knockout cell line (HeLa) Human NUMA1 1:3~1:6 Negative Online Inquiry
KO36293 NUMA1 Knockout cell line (HCT 116) Human NUMA1 1:2~1:4 Negative Online Inquiry

Background

NUMA1 Gene Knockout Cell Lines are specialized cellular models engineered to study the functional significance of the NUMA1 gene, which is crucial for proper mitotic spindle assembly and stability during cell division. Utilizing CRISPR-Cas9 gene editing technology, these knockout cell lines lack the expression of the NUMA1 gene, allowing researchers to investigate the role of NUMA1 in various cellular processes such as mitosis, cellular polarization, and developmental biology.

The primary function of these cell lines is to provide a robust platform for understanding the consequences of NUMA1 deficiency. By analyzing phenotypic changes in cell division, migration, and differentiation, researchers can elucidate NUMA1's involvement in fundamental biological processes and its implications in diseases such as cancer, where dysregulation of mitotic machinery is common. Additionally, these cell lines can be employed to screen for potential therapeutic targets, making them invaluable in translational research.

The scientific importance of NUMA1 Knockout Cell Lines cannot be overstated; they enable the dissection of complex pathways and cellular mechanisms that underlie many ailments, thereby paving the way for groundbreaking discoveries in both basic and applied research. Compared to alternative models, these knockout lines offer a higher degree of specificity and reliability for assessing gene function, backed by the precise nature of the CRISPR-Cas9 system.

What sets our NUMA1 Gene Knockout Cell Lines apart is not just their high-quality construction and characterization but also our guarantee of reproducibility and ongoing support for experimental design. Researchers and clinicians alike will find value in their ability to advance knowledge of genetic contributions to cellular behavior, contributing to innovations in cancer treatment and regenerative medicine.

With expertise in genetic engineering and cellular biology, our company is committed to providing exceptional biological products, ensuring that researchers have the tools they need to drive scientific innovation forward.

Please note that all services are for research use only. Not intended for any clinical use.

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