Gene: NUDT3
Official Full Name: nudix hydrolase 3provided by HGNC
Gene Summary: NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31139 | NUDT3 Knockout cell line (HeLa) | Human | NUDT3 | 1:3~1:6 | Negative | Online Inquiry |
KO31140 | NUDT3 Knockout cell line (HCT 116) | Human | NUDT3 | 1:2~1:4 | Negative | Online Inquiry |
KO31141 | NUDT3 Knockout cell line (HEK293) | Human | NUDT3 | 1:3~1:6 | Negative | Online Inquiry |
KO31142 | NUDT3 Knockout cell line (A549) | Human | NUDT3 | 1:3~1:4 | Negative | Online Inquiry |
NUDT3 Gene Knockout Cell Lines are specially engineered human cell lines that possess a specific deletion of the NUDT3 gene, which encodes an enzyme involved in nucleotide metabolism and cellular stress response. Through precise genetic editing techniques such as CRISPR-Cas9, these cell lines offer researchers a powerful tool to elucidate the biological functions and pathways moderated by NUDT3. The deletion of this gene provides insights into its role in various cellular processes, including signaling pathways related to tumorigenesis, apoptosis, and inflammation.
The NUDT3 gene is crucial for the hydrolysis of nucleoside diphosphates, playing a significant role in cellular energy metabolism. By utilizing our knockout cell lines, scientists can investigate alterations in energy homeostasis, the response to oxidative stress, and the potential implications of NUDT3 dysfunction in diseases such as cancer and neurodegeneration. The functionality of these cell lines aids in the development of targeted therapies and revealing new biomolecular interactions, making them invaluable in both basic and translational research settings.
What sets NUDT3 Gene Knockout Cell Lines apart from other models is their precision and reliability. Established in a standardized laboratory environment and tested for reproducibility, these cell lines provide robust experimental systems compared to traditional knockout models, which may present variability in gene expression levels or cellular response. These cell lines can be easily integrated into high-throughput screening processes, enabling efficient drug discovery and biomarker identification.
For researchers and clinicians seeking comprehensive insights into gene function or disease mechanisms, NUDT3 Gene Knockout Cell Lines represent a unique asset. They not only streamline the experimental process but also enhance the accuracy and reproducibility of research findings. With our extensive expertise in cell line development and genetic engineering, we are committed to providing high-quality biological products that advance scientific discovery in genetics and cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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