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NUCB2 Knockout Cell Lines

Gene: NUCB2

Official Full Name: nucleobindin 2provided by HGNC

Gene Summary: This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36294 NUCB2 Knockout cell line (HeLa) Human NUCB2 1:3~1:6 Negative Online Inquiry
KO36295 NUCB2 Knockout cell line (HCT 116) Human NUCB2 1:2~1:4 Negative Online Inquiry
KO36296 NUCB2 Knockout cell line (HEK293) Human NUCB2 1:3~1:6 Negative Online Inquiry
KO36297 NUCB2 Knockout cell line (A549) Human NUCB2 1:3~1:4 Negative Online Inquiry

Background

NUCB2 Gene Knockout Cell Lines are specifically engineered cellular models that lack the expression of the NEUROCHONDRIN 2 (NUCB2) gene. This gene encodes a protein involved in crucial neuroendocrine signaling pathways, impacting various physiological processes, including energy homeostasis and appetite regulation. By utilizing CRISPR-Cas9 technology, these cell lines provide researchers with a powerful tool to dissect the roles of NUCB2 in both normal and disease states, facilitating a deeper understanding of its functions at a molecular level.

Key functions of the NUCB2 gene knockout cell lines include their ability to simulate conditions of reduced NUCB2 signaling, thereby allowing for the examination of downstream effects on cellular processes such as neurotransmitter release, hormone secretion, and neuropeptide synthesis. These cell lines serve as indispensable models in elucidating the mechanistic underpinnings of metabolic disorders, obesity, and related neuroendocrine dysfunctions, making them a pivotal asset in both academic and pharmaceutical research settings.

The scientific importance of these cell lines extends to their application in drug discovery and development, particularly in screening potential therapeutics targeting neuroendocrine pathways. Their unique ability to mimic pathophysiological states associated with altered NUCB2 signaling offers researchers a differentiated approach compared to traditional models. Furthermore, NUCB2 Gene Knockout Cell Lines provide unparalleled reproducibility and versatility, allowing for easier integration with high-throughput screening systems or co-culture models.

What sets our NUCB2 Gene Knockout Cell Lines apart from alternatives is their enhanced specificity and reliability, derived from our rigorous quality control processes and our commitment to providing detailed characterization data. These features empower researchers to gain confidence in their experimental outcomes, translating into more robust data for publications or clinical applications.

In conclusion, NUCB2 Gene Knockout Cell Lines represent a significant advancement for researchers and clinicians seeking to explore the complexities of neuroendocrine biology. Our company prides itself on its expertise in genetic engineering and commitment to delivering high-quality biological products that meet the evolving needs of the scientific community. By integrating state-of-the-art gene manipulation techniques with comprehensive support, we aim to advance scientific discovery and innovation in the realm of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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