Gene: NTN4
Official Full Name: netrin 4provided by HGNC
Gene Summary: This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15598 | NTN4 Knockout cell line (HeLa) | Human | NTN4 | 1:3~1:6 | Negative | Online Inquiry |
KO15599 | NTN4 Knockout cell line (HCT 116) | Human | NTN4 | 1:2~1:4 | Negative | Online Inquiry |
KO15600 | NTN4 Knockout cell line (HEK293) | Human | NTN4 | 1:3~1:6 | Negative | Online Inquiry |
KO15601 | NTN4 Knockout cell line (A549) | Human | NTN4 | 1:3~1:4 | Negative | Online Inquiry |
NTN4 Gene Knockout Cell Lines are specialized cell cultures genetically modified to disrupt the expression of the NTN4 gene, which encodes for the protein Netrin-4. These cell lines serve as invaluable tools for understanding the role of NTN4 in various biological processes, including cellular signaling, neuronal guidance, and tissue development. By creating a knockout model, researchers can effectively analyze the specific contributions of NTN4 to cellular function and pathology.
The key mechanism through which NTN4 Gene Knockout Cell Lines operate is the complete ablation of NTN4 protein production, allowing for the observation of phenotypic changes that occur in the absence of this growth factor. This model system enables scientists to elucidate NTN4's involvement in diseases such as cancer, neurodegenerative disorders, and developmental abnormalities. By investigating how the loss of NTN4 impacts cellular behaviors, researchers can gain insights into potential therapeutic targets or biological pathways influenced by this protein.
The scientific importance of NTN4 Gene Knockout Cell Lines extends to both basic research and clinical applications, as they provide a controlled environment for experimental studies aimed at understanding the complex interactions between NTN4 and various signaling networks. In comparison to alternative approaches, such as transient knockdown methodologies, our knockout cell lines offer stable and reproducible loss-of-function models that lead to more reliable data generation over extended periods.
What sets NTN4 Gene Knockout Cell Lines apart is their potential for diverse applications in drug discovery, personalized medicine, and the study of genetic diseases. Researchers and clinicians can utilize these models to test the effects of novel compounds on NTN4-related pathways or to explore compensation mechanisms and plasticity in NTN4 signaling.
At [Your Company Name], we pride ourselves on our expertise in generating high-quality biological products designed for ground-breaking research. Our NTN4 Gene Knockout Cell Lines are developed through cutting-edge techniques and are rigorously tested for reliability, providing researchers with robust tools to enhance their scientific inquiries and discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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