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NSFL1C Knockout Cell Lines

Gene: NSFL1C

Official Full Name: NSFL1 cofactorprovided by HGNC

Gene Summary: N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05526 NSFL1C Knockout cell line (HeLa) Human NSFL1C 1:3~1:6 Negative Online Inquiry
KO05527 NSFL1C Knockout cell line (HCT 116) Human NSFL1C 1:2~1:4 Negative Online Inquiry
KO05528 NSFL1C Knockout cell line (HEK293) Human NSFL1C 1:3~1:6 Negative Online Inquiry
KO05529 NSFL1C Knockout cell line (A549) Human NSFL1C 1:3~1:4 Negative Online Inquiry

Background

NSFL1C Gene Knockout Cell Lines represent a cutting-edge tool for researchers investigating the role of the NSFL1C gene, which encodes a protein involved in diverse cellular processes including protein trafficking and degradation. By providing a cellular model where the NSFL1C gene has been systematically inactivated, these cell lines enable detailed examination of the gene's functional assays and pathways, enhancing our understanding of its contribution to cellular homeostasis and disease mechanisms.

The primary mechanism of these knockout cell lines hinges on the CRISPR-Cas9 gene-editing technology, which facilitates precise and efficient disruption of the NSFL1C gene. This targeted approach ensures that researchers can study the resulting phenotypic changes with high specificity, allowing for the delineation of the gene’s role in cellular processes such as autophagy and stress response. Furthermore, these cell lines serve as critical tools for drug discovery and development, specifically for identifying potential therapeutic targets in disorders linked to protein misfolding and mitochondrial dysfunction.

Scientific importance and applications for NSFL1C Gene Knockout Cell Lines extend into a variety of research areas, including neurobiology, cancer research, and immunology. Their application in vitro can lead to critical insights that may translate into clinical advancements. By utilizing these knockout models, researchers can streamline the validation of hypotheses regarding gene function, allowing for a quicker progression from laboratory bench to bedside.

The unique selling points of NSFL1C Gene Knockout Cell Lines lie in their validated performance and reproducibility, complemented by a user-friendly format that adheres to rigorous quality controls. Compared to traditional methods such as siRNA or shRNA, CRISPR-mediated knockouts provide complete gene inactivation, yielding more definitive results in functional studies and reducing off-target effects.

For researchers, clinicians, and pharmaceutical developers, the value of NSFL1C Gene Knockout Cell Lines is clear. They offer an unparalleled opportunity to dissect the biological roles of NSFL1C, thus contributing significantly to the understanding of related pathologies and intervention strategies. Our company is at the forefront of biotechnological innovation, offering prowess and experience in generating specialized biological products that empower scientific research and advancement in therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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