Gene: NRP2
Official Full Name: neuropilin 2provided by HGNC
Gene Summary: This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33807 | NRP2 Knockout cell line (HeLa) | Human | NRP2 | 1:3~1:6 | Negative | Online Inquiry |
KO33808 | NRP2 Knockout cell line (HEK293) | Human | NRP2 | 1:3~1:6 | Negative | Online Inquiry |
KO33809 | NRP2 Knockout cell line (A549) | Human | NRP2 | 1:3~1:4 | Negative | Online Inquiry |
NRP2 Gene Knockout Cell Lines are specialized cell lines that have undergone targeted gene editing to create a complete and functional knockout of the neuropilin-2 (NRP2) gene. NRP2 is a critical receptor involved in various biological processes, including neuronal development, vascular remodeling, and immune responses. By eliminating the expression of this gene, researchers can effectively investigate the functional role of NRP2 in cellular pathways and disease models.
The key function of NRP2 knockout cell lines lies in their ability to elucidate the molecular mechanisms underlying neurogenesis and angiogenesis while providing insights into potential therapeutic targets for conditions such as cancer and neurodegenerative diseases. The knockout process typically employs CRISPR-Cas9 technology, ensuring precise alterations in the genomic sequence of the NRP2 gene. When subjected to experimental manipulation, these cell lines can serve as models for assessing the impact of NRP2 on cellular behavior, morphology, and signaling pathways.
From a scientific perspective, NRP2 knockout cell lines are invaluable tools in both basic and applied research fields, particularly in studies exploring tumor progression, neuronal plasticity, and the immune microenvironment. Their innovative use in preclinical research can accelerate drug discovery processes and the development of targeted therapies, thereby bridging the gap between laboratory findings and clinical applications.
Compared to alternative models, NRP2 knockout cell lines offer distinct advantages, including the specificity of genetic alteration, the ability to produce repeatable results, and the availability of various background cell types to fit specific research needs. Additionally, these cell lines provide a controlled environment for in vitro studies, reducing variability typically seen in animal models.
For researchers and clinicians invested in understanding the complexities of NRP2’s role in health and disease, these knockout cell lines present an exceptional value proposition. They empower scientists to conduct innovative research that can lead to groundbreaking medical advancements. With our extensive expertise in genetic engineering and a commitment to high-quality biological products, our company ensures that these NRP2 Gene Knockout Cell Lines meet rigorous standards of reliability and effectiveness for all your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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