NR1H3 Knockout Cell Lines

NR1H3 gene knockout cell lines are specifically engineered cellular models in which the NR1H3 gene, also known as liver X receptor alpha (LXRα), has been inactivated. These cell lines serve as powerful tools for studying the role of LXRα in various biological processes, including lipid metabolism, inflammation, and glucose homeostasis. This gene encodes a nuclear receptor that plays a crucial role in regulating cholesterol and fatty acid metabolism through its action as a transcription factor. By knocking out NR1H3, researchers can investigate the downstream metabolic consequences and the receptor's involvement in disease mechanisms such as atherosclerosis, diabetes, and obesity-related disorders.

The primary function of NR1H3 in cellular contexts involves the modulation of gene expression in response to oxysterols and other lipid derivatives. Upon ligand binding, LXRα forms heterodimers with retinoid X receptors, thus influencing transcriptional activity of target genes. The knockout of this gene allows scientists to delineate the regulatory pathways associated with NR1H3, offering insights into both normal physiological processes and pathophysiological conditions.

In research and clinical applications, NR1H3 knockout cell lines are invaluable for drug discovery, particularly in developing therapeutics targeting metabolic diseases. They provide an effective platform for screening potential LXR-modulating compounds, thus facilitating the identification of novel therapeutic agents. Compared to alternatives, such as wild-type cell lines, NR1H3 knockout models offer clear advantages by providing a controlled environment to study the absence of LXRα and its associated effects.

For researchers and clinicians focused on metabolic health, these cell lines represent a critical resource, enabling a deeper understanding of how the modulation of nuclear receptors can impact disease progression and treatment efficacy. Furthermore, our company brings extensive expertise in genetic engineering and cellular model development, ensuring that our NR1H3 knockout cell lines are of the highest quality and utility. This commitment to excellence empowers our customers to generate reliable data and translates into advancements in their research endeavors.