Gene: NPR2
Official Full Name: natriuretic peptide receptor 2provided by HGNC
Gene Summary: This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07517 | NPR2 Knockout cell line (HeLa) | Human | NPR2 | 1:3~1:6 | Negative | Online Inquiry |
KO07518 | NPR2 Knockout cell line (HCT 116) | Human | NPR2 | 1:2~1:4 | Negative | Online Inquiry |
KO07519 | NPR2 Knockout cell line (HEK293) | Human | NPR2 | 1:3~1:6 | Negative | Online Inquiry |
KO07520 | NPR2 Knockout cell line (A549) | Human | NPR2 | 1:3~1:4 | Negative | Online Inquiry |
NPR2 Gene Knockout Cell Lines are genetically engineered cellular models designed to study the functional implications of the NPR2 gene, which is crucial for various physiological processes, particularly those involving nitric oxide signaling and cGMP metabolism. These cell lines facilitate the investigation of NPR2's role in cardiovascular health, reproductive functions, and certain pathologies such as pulmonary hypertension and gynecological disorders.
The key function of these cell lines lies in their ability to provide a controlled environment to examine the absence of the NPR2 gene. By knocking out this specific gene, researchers can elucidate its contribution to signaling pathways and assess downstream biological effects, such as alterations in cellular responses to hormonal stimuli. The mechanisms by which the NPR2 knockout influences cell behavior can provide insights into both normal physiology and disease states, empowering researchers to design targeted interventions.
With their application spanning both basic research and clinical settings, NPR2 Gene Knockout Cell Lines serve as invaluable tools for drug development, genetic studies, and the exploration of gene therapy approaches. They can accelerate the discovery of novel biomarkers and therapeutic targets, facilitating the advancement of personalized medicine.
One of the distinctive advantages of our NPR2 Gene Knockout Cell Lines over alternative models is their high fidelity and reproducibility, ensuring that experimental results are reliable and translatable. Furthermore, our lines are optimized for a variety of assays, from cell proliferation studies to detailed mechanistic investigations, making them versatile tools for diverse research applications.
Researchers and clinicians will find exceptional value in deploying these cell lines in their studies. The precision of the NPR2 knockout allows for definitive conclusions regarding gene function, ultimately leading to breakthroughs in therapeutic approaches for related diseases.
With decades of expertise in biotechnology and cell line development, our company is dedicated to providing high-quality, tailored biological tools that meet the evolving needs of the scientific community. We remain committed to advancing research through innovative solutions such as our NPR2 Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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