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NOX5 Knockout Cell Lines

Gene: NOX5

Official Full Name: NADPH oxidase 5provided by HGNC

Gene Summary: Enables proton channel activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including endothelial cell proliferation; proton transmembrane transport; and superoxide anion generation. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00610 NOX5 Knockout cell line(HEK293) Human NOX5 1:3~1:6 Negative Online Inquiry

Background

NOX5 Gene Knockout Cell Lines represent a powerful tool in the field of molecular biology, specifically designed for the study of NADPH oxidase 5 (NOX5), a critical enzyme involved in the production of reactive oxygen species. These cell lines are genetically modified to lack functional NOX5 genes, providing a unique platform for researchers to investigate the enzyme's physiological and pathological roles. By eliminating NOX5, scientists can elucidate its involvement in various signaling pathways, cellular responses to oxidative stress, and the mechanisms underlying cardiovascular, neurodegenerative, and cancer-related diseases.

The key mechanism behind these knockout cell lines is gene editing, typically achieved through techniques such as CRISPR-Cas9. This precise modification enables researchers to observe the resultant phenotypic changes, empowering them to understand the removal's effects on cellular function and signaling. The relevance of NOX5 in human health highlights its potential as a therapeutic target, with these knockout lines serving as valuable models for drug discovery and the exploration of novel therapeutic interventions.

One of the significant advantages of the NOX5 Gene Knockout Cell Lines is their specificity and reliability compared to other gene deletion methods, allowing for reproducible results and enhanced understanding of NOX5's various roles. Unlike traditional methods that may yield variable outcomes or off-target effects, these knockout cell lines provide a consistent platform, facilitating robust experimental designs and high-quality results.

For researchers and clinicians working in pharmacology, cancer biology, and oxidative stress research, these cell lines are invaluable for advancing our understanding of NOX5 function and its implications in health and disease. The practical applications include the evaluation of potential inhibitors, investigations into the enzymatic roles of NOX5 in cellular signaling, and studying the overall impact of oxidative stress on cellular physiology.

Our company, dedicated to advancing research in molecular biology, leverages extensive expertise and cutting-edge technology to produce high-quality biological products. The NOX5 Gene Knockout Cell Lines are a testament to our commitment to providing the scientific community with the tools necessary to deepen their understanding of complex cellular processes and develop innovative solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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