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NOMO3 Knockout Cell Lines

Gene: NOMO3

Official Full Name: NODAL modulator 3provided by HGNC

Gene Summary: This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21042 NOMO3 Knockout cell line (HeLa) Human NOMO3 1:3~1:6 Negative Online Inquiry
KO21043 NOMO3 Knockout cell line (HCT 116) Human NOMO3 1:2~1:4 Negative Online Inquiry
KO21044 NOMO3 Knockout cell line (HEK293) Human NOMO3 1:3~1:6 Negative Online Inquiry
KO21045 NOMO3 Knockout cell line (A549) Human NOMO3 1:3~1:4 Negative Online Inquiry

Background

NOMO3 Gene Knockout Cell Lines are genetically engineered models wherein the NOMO3 gene has been selectively inactivated. These cell lines serve as critical tools for studying the functional role of the NOMO3 gene in various biological processes, notably in developmental pathways and cellular signaling mechanisms. By employing CRISPR-Cas9 technology or homologous recombination, scientists can create precise mutations that eliminate the expression of the NOMO3 protein, thereby facilitating functional assays to investigate its contributions to cellular behavior and disease states.

Key functions of NOMO3 revolve around its involvement in the regulation of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and embryonic development. By utilizing NOMO3 knockout cell lines, researchers can dissect the specific cellular processes influenced by NOMO3, thus providing insights into potential pathophysiological mechanisms underlying various conditions such as cancer, developmental disorders, and other signaling-related diseases.

The scientific importance of these cell lines extends into both research and clinical settings. They are vital for screening therapeutic compounds, elucidating drug targets, and developing strategies to modulate signaling pathways in disease contexts. Researchers can leverage these models to investigate gene function and interactions in a controlled environment, significantly enhancing the reliability of experimental outcomes.

What sets NOMO3 Gene Knockout Cell Lines apart from alternative models is their specificity and precision in targeting the NOMO3 gene. Unlike conventional knockdown approaches, knockout models provide a complete loss-of-function capability, giving a clearer picture of phenotypic consequences. Furthermore, these cell lines enable reproducibility and scalability for high-throughput screening applications, making them an invaluable resource for pharmaceutical research and biotechnology.

In summary, leveraging NOMO3 Gene Knockout Cell Lines empowers researchers and clinicians to unlock biomedical mysteries, drive innovative therapies, and enhance our understanding of human health and disease. Our company is committed to providing high-quality, validated cell line models alongside unparalleled support, backed by extensive expertise in genetic engineering and cellular biology, ensuring that you have the best resources to advance your research.

Please note that all services are for research use only. Not intended for any clinical use.

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