Gene: NLN
Official Full Name: neurolysinprovided by HGNC
Gene Summary: This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00407 | NLN Knockout cell line (HEK293) | Human | NLN | 1:3~1:6 | Negative | Online Inquiry |
KO15713 | NLN Knockout cell line (HeLa) | Human | NLN | 1:3~1:6 | Negative | Online Inquiry |
KO15714 | NLN Knockout cell line (HCT 116) | Human | NLN | 1:2~1:4 | Negative | Online Inquiry |
KO15715 | NLN Knockout cell line (A549) | Human | NLN | 1:3~1:4 | Negative | Online Inquiry |
NLN Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate functional studies of the neurosecretory peptide neurolysin (NLN). These cell lines utilize precise CRISPR-Cas9 gene editing technology to disrupt the NLN gene, creating a model where the biological functions associated with NLN can be thoroughly explored. By providing a system free from the endogenous production of this peptide, researchers can assess its role in various biological processes, from neurodevelopment to osteogenic differentiation.
The key function of NLN Gene Knockout Cell Lines lies in their ability to allow scientists to evaluate the mechanistic pathways influenced by NLN and its downstream effects on cellular behavior. By comparing these knockout cell lines with wild-type cells, researchers can delineate NLN's contribution to neuropeptide signaling, neuroprotection, and potential implications in neurodegenerative diseases. Furthermore, these cell lines provide an essential tool for drug discovery and toxicology studies, offering a platform to identify novel therapeutic targets for conditions where NLN is involved.
The scientific importance of these knockout models cannot be overstated, as they bridge the gap between in vitro research and potential clinical applications. Such models support the elucidation of NLN's role in health and disease, ultimately guiding deeper investigations that could lead to innovative therapeutic strategies.
Compared to traditional knockout models, which may be cumbersome and time-consuming to develop, NLN Gene Knockout Cell Lines offer a quick-to-establish resource with validated functionality. The speed of generating reproducible data enhances the efficiency of research timelines, allowing laboratories to focus on critical discoveries.
For researchers and clinicians dedicated to unraveling the complexities of neurobiology, these cell lines are invaluable, providing precise experimental control and insight into the potential of NLN as a therapeutic target.
Our company prides itself on pioneering advancements in cellular models and gene editing technologies, positioning us at the forefront of genetic tools that empower scientific discovery. As leaders in biological product innovation, we are committed to supporting your research endeavors with high-quality tools that drive impactful research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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