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NLK Knockout Cell Lines

Gene: NLK

Official Full Name: nemo like kinaseprovided by HGNC

Gene Summary: Enables DNA-binding transcription factor binding activity; protein serine/threonine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of TORC1 signaling; protein stabilization; and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10586 NLK Knockout cell line (HeLa) Human NLK 1:3~1:6 Negative Online Inquiry
KO10587 NLK Knockout cell line (HCT 116) Human NLK 1:2~1:4 Negative Online Inquiry
KO10588 NLK Knockout cell line (HEK293) Human NLK 1:3~1:6 Negative Online Inquiry
KO10589 NLK Knockout cell line (A549) Human NLK 1:3~1:4 Negative Online Inquiry

Background

NLK Gene Knockout Cell Lines are genetically modified cell lines in which the NLK (Nemo-like kinase) gene has been systematically disrupted or "knocked out." This innovative biological product is essential for the study of NLK's role in cellular signaling pathways, development, cancer biology, and other physiological processes. By eliminating the function of the NLK gene, these cell lines provide a unique platform for researchers to investigate the gene's contributions to various cellular behaviors, including cell proliferation, differentiation, and apoptosis.

The mechanisms underpinning NLK's function involve the regulation of several key signaling pathways, such as Wnt, MAPK, and NF-kB pathways. These pathways are crucial for maintaining cellular homeostasis and mediating responses to external stimuli. By utilizing NLK gene knockout cell lines, scientists can dissect the specific contributions of NLK to these pathways, facilitating a deeper understanding of its biological roles and potential implications for therapeutic targets.

The scientific importance of NLK gene knockout cell lines extends to both research and clinical applications. In research settings, these cell lines serve as invaluable tools for drug development, allowing for the screening of therapeutic compounds that target NLK-associated pathways. Clinically, findings derived from these studies may lead to novel interventions for diseases wherein NLK is implicated, such as various cancers.

A significant advantage of NLK gene knockout cell lines over traditional methods, such as transient gene silencing or pharmacological inhibitors, is their stability and specificity. These cell lines provide a consistent and reproducible framework for long-term studies, enhancing the reliability of experimental data. Additionally, they enable researchers to investigate compensatory mechanisms that may arise from the absence of the NLK gene, which is often overlooked in transient knockdown studies.

For researchers and clinicians alike, the ability to access NLK gene knockout cell lines represents a pivotal step toward unlocking new insights into cellular processes and disease mechanisms. This product not only enhances research capabilities but also holds promise for fostering advancements in therapeutic strategies.

Our company prides itself on its commitment to precision genetics and state-of-the-art technology in gene editing. With a focus on delivering high-quality biological products, we ensure that our NLK Gene Knockout Cell Lines are meticulously validated, making them a trusted resource for the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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