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NLGN4X Knockout Cell Lines

Gene: NLGN4X

Official Full Name: neuroligin 4 X-linkedprovided by HGNC

Gene Summary: This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00877 NLGN4X Knockout cell line(MDA-MB-231) Human NLGN4X 1:2~1:4 Negative Online Inquiry

Background

NLGN4X Gene Knockout Cell Lines are expertly engineered cellular models that enable researchers to study the function and implications of the NLGN4X gene, which is linked to neurodevelopmental disorders, including autism spectrum disorders. These cell lines have undergone precise CRISPR-Cas9 gene editing to effectively eliminate the expression of the NLGN4X gene, allowing for an in-depth analysis of its biological role and related pathways without the interference of NLGN4X activity.

The primary function of these knockout cell lines is to serve as a platform for investigating the molecular mechanisms by which the absence of NLGN4X affects neuronal connectivity and synaptic function. By employing these models, scientists can assess changes in gene expression profiles, protein interactions, and signaling pathways that may contribute to neurodevelopmental alterations. Furthermore, these cell lines can be used for drug discovery, providing insights into potential therapeutic targets that may mitigate the effects associated with NLGN4X loss.

The scientific importance of NLGN4X Gene Knockout Cell Lines is profound. They enable advances in understanding complex neuronal mechanisms, making them invaluable in research settings focused on neurobiology and psychiatric disorders. In clinical research, these models have potential applications for screening pharmacological agents aimed at restoring synaptic integrity or improving cognitive function.

What sets our NLGN4X Gene Knockout Cell Lines apart is their high specificity and reliability, coupled with the robust validation of editing efficiency. Unlike traditional models that may exhibit variable effects due to incomplete knockdowns, our cell lines provide a consistent and reproducible system for experimentation. This reliability significantly enhances the credibility of research findings.

In summary, NLGN4X Gene Knockout Cell Lines stand out as a critical tool for researchers and clinicians alike, offering the unique ability to explore the underpinnings of neurodevelopmental disorders with precision. Our company is dedicated to advancing scientific understanding and therapeutic development, reinforced by our expertise in cutting-edge genetic engineering technologies and a commitment to providing high-quality biological products that support groundbreaking research initiatives.

Please note that all services are for research use only. Not intended for any clinical use.

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