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NKX3-2 Knockout Cell Lines

Gene: NKX3-2

Official Full Name: NK3 homeobox 2provided by HGNC

Gene Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation; negative regulation of chondrocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including intestinal epithelial cell development; middle ear morphogenesis; and skeletal system development. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38834 NKX3-2 Knockout cell line (HeLa) Human NKX3-2 1:3~1:6 Negative Online Inquiry
KO38835 NKX3-2 Knockout cell line (HEK293) Human NKX3-2 1:3~1:6 Negative Online Inquiry

Background

NKX3-2 Gene Knockout Cell Lines are a specialized set of cellular models designed for the in-depth study of the NKX3-2 gene, which plays a critical role in development and differentiation processes, particularly in embryogenesis and organ formation. These knockout cell lines are generated through precise gene-editing technologies, such as CRISPR/Cas9, rendering specific mutations in the NKX3-2 gene, allowing researchers to dissect its functional implications in various biological contexts.

The primary function of these cell lines is to enable the exploration of the NKX3-2 gene's regulatory mechanisms and its downstream signaling pathways. By utilizing these knockout models, scientists can investigate the phenotypic consequences of NKX3-2 disruption, elucidating its contribution to developmental biology and potential linkages to diseases, including certain cancers. The ability to manipulate and observe the resultant cellular behaviors provides invaluable insights into genetic interactions and cellular responses, making these models essential for advancing our understanding of gene function.

In a clinical setting, NKX3-2 gene knockout cell lines hold significant promise for drug discovery and cancer research, as they can be employed to screen for new therapeutic compounds that target specific pathways influenced by NKX3-2. Compared to standard cell lines, these knockout models offer a more authentic representation of gene function, enabling more robust and translationally relevant results.

The unique selling point of NKX3-2 Gene Knockout Cell Lines lies in their specialized application for understanding gene function in a controlled environment, allowing for high-throughput screening and the ability to generate reproducible data. Additionally, as knockout models, they alleviate issues of off-target effects that can distort findings, which are prevalent in traditional models.

These cell lines are invaluable to researchers and clinicians interested in developmental biology, cancer research, and genetic studies, providing the tools necessary for groundbreaking discoveries that could pave the way for new diagnostics or targeted therapies. Our company is dedicated to delivering high-quality biological products backed by extensive expertise in genetic research and cell line development, ensuring that our offerings are aligned with the needs of modern scientific investigation.

Please note that all services are for research use only. Not intended for any clinical use.

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