Gene: NIT1
Official Full Name: nitrilase 1provided by HGNC
Gene Summary: This gene encodes a member of the nitrilase protein family with homology to bacterial and plant nitrilases, enzymes that cleave nitriles and organic amides to the corresponding carboxylic acids plus ammonia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36344 | NIT1 Knockout cell line (HeLa) | Human | NIT1 | 1:3~1:6 | Negative | Online Inquiry |
KO36345 | NIT1 Knockout cell line (HCT 116) | Human | NIT1 | 1:2~1:4 | Negative | Online Inquiry |
KO36346 | NIT1 Knockout cell line (HEK293) | Human | NIT1 | 1:3~1:6 | Negative | Online Inquiry |
KO36347 | NIT1 Knockout cell line (A549) | Human | NIT1 | 1:3~1:4 | Negative | Online Inquiry |
NIT1 Gene Knockout Cell Lines are specialized cellular models genetically engineered to lack the NIT1 gene, which encodes for enzymes involved in the metabolism of certain amino acids and purines. By implementing CRISPR/Cas9 gene editing technology, these cell lines facilitate the exploration of the NIT1 gene's role in cellular processes and its potential implications in disease mechanisms, particularly in metabolic disorders and cancer research.
The key functionality of NIT1 Gene Knockout Cell Lines lies in their utility as a controlled system to study the downstream effects of NIT1 gene disruption. Researchers can observe alterations in metabolic pathways, assess compensatory mechanisms, and conduct drug response assays, which are critical for deciphering the biochemical networks regulated by the NIT1 gene. The knockout model allows for precise elucidation of gene function and characterization of phenotypic changes that may arise due to the absence of NIT1, providing invaluable insights into its biological significance.
Importantly, these cell lines hold significant scientific value in both research and clinical applications. They contribute to the understanding of metabolic syndromes, neurodegenerative diseases, and tumor biology, serving as a platform for developing new therapeutic strategies. Furthermore, the use of NIT1 Gene Knockout Cell Lines can enhance the reliability of experimental data when validating hypotheses or testing novel compounds in drug development pipelines.
Compared to conventional cell lines, these knockout models offer specificity that allows researchers to dissect the impact of the NIT1 gene, drastically reducing background noise from confounding genes. Their ready-to-use format streamlines experimental workflows and accelerates the pace of research, making them an attractive choice for laboratories aiming for precision in their investigations.
For researchers and clinicians focused on advancing their knowledge of gene function and disease mechanisms, NIT1 Gene Knockout Cell Lines are a powerful tool with the potential to unlock new therapeutic avenues. Our company, renowned for our expertise in genomic engineering and biological products, ensures that each cell line is rigorously validated and prepared to meet the high standards of scientific research, enabling our clients to drive impactful discoveries in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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