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NHS Knockout Cell Lines

Gene: NHS

Official Full Name: NHS actin remodeling regulatorprovided by HGNC

Gene Summary: This gene encodes a protein containing four conserved nuclear localization signals. The encoded protein functions in eye, tooth, craniofacial and brain development, and it can regulate actin remodeling and cell morphology. Mutations in this gene have been shown to cause Nance-Horan syndrome, and also X-linked cataract-40. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36361 NHS Knockout cell line (HeLa) Human NHS 1:3~1:6 Negative Online Inquiry
KO36362 NHS Knockout cell line (HCT 116) Human NHS 1:2~1:4 Negative Online Inquiry
KO36363 NHS Knockout cell line (HEK293) Human NHS 1:3~1:6 Negative Online Inquiry
KO36364 NHS Knockout cell line (A549) Human NHS 1:3~1:4 Negative Online Inquiry

Background

NHS Gene Knockout Cell Lines represent a cutting-edge biological tool specifically designed to facilitate gene function studies and elucidate the roles of specific genes in various cellular processes. These genetically engineered cell lines are created using advanced CRISPR-Cas9 technology, which allows for precise gene editing by introducing targeted deletions or insertions. As a result, researchers can effectively produce knockout models that help reveal the consequences of gene loss, making these cell lines invaluable for functional genomics.

The primary mechanism of action for the NHS Gene Knockout Cell Lines revolves around gene deletion and subsequent phenotype analysis. Once a specific gene is knocked out, researchers can observe changes in cellular behavior, including alterations in signaling pathways, metabolic processes, and response to drugs. Such insights play a crucial role in understanding disease mechanisms, drug development, and identifying potential therapeutic targets.

Scientific applications of these knockout cell lines are vast. They are instrumental in research settings, enabling scientists to investigate a plethora of biological questions ranging from cancer biology, immunology, and developmental biology to neurological disorders. Clinically, these cell lines serve as models for drug screening and toxicity testing, bridging the gap between basic research and clinical application.

One notable advantage of the NHS Gene Knockout Cell Lines is their high specificity and efficiency in gene targeting, which outperforms traditional knockout techniques such as homologous recombination. Furthermore, these cell lines come with validated performance metrics and comprehensive documentation that streamline experimental workflows, saving researchers valuable time and resources.

For researchers and clinicians seeking to deepen their understanding of gene function, the NHS Gene Knockout Cell Lines provide a reliable and reproducible tool that opens avenues for impactful discoveries. Our commitment to excellence in biological product development has positioned us as a trusted partner in facilitating groundbreaking research and clinical innovation, ensuring that our products meet the highest standards in the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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