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NFASC Knockout Cell Lines

Gene: NFASC

Official Full Name: neurofascinprovided by HGNC

Gene Summary: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29854 NFASC Knockout cell line (A549) Human NFASC 1:3~1:4 Negative Online Inquiry

Background

NFASC Gene Knockout Cell Lines are specifically engineered cellular models in which the NFASC gene has been inactivated through targeted gene editing techniques, such as CRISPR-Cas9. These cell lines are essential for studying the functions and regulatory mechanisms of the NFASC gene, which encodes for the neurofascin protein, a critical component in the formation of myelin sheaths in the nervous system.

The primary function of these knockout cell lines is to elucidate the role of neurofascin in cellular processes such as axonal conduction, myelination, and cell adhesion. By eliminating functional NFASC expression, researchers can investigate the downstream effects on neuronal signaling and myelination, ultimately contributing to our understanding of neurodegenerative diseases and demyelinating conditions.

The scientific importance of NFASC Gene Knockout Cell Lines is underscored by their applicability in both basic and translational research settings. These models facilitate in-depth studies into the molecular pathways involving neurofascin and offer a robust platform for developing therapeutic strategies for conditions such as multiple sclerosis and Charcot-Marie-Tooth disease, where myelin integrity is compromised.

One significant advantage of our NFASC Gene Knockout Cell Lines is their high specificity and reproducibility compared to traditional knockout models, which may have off-target effects. Additionally, our cell lines come validated with comprehensive characterization data that ensures reliable performance and consistent results. This reliability not only saves time but also enhances the quality of experimental outcomes.

For researchers and clinicians, the availability of NFASC Gene Knockout Cell Lines represents a valuable resource for unlocking new insights into neurological function and disease. Their potential to accelerate discoveries and contribute to the development of innovative treatment approaches makes them an essential tool in today’s biologically focused research landscape.

At our company, we specialize in providing high-quality biological products, supported by cutting-edge technology and a commitment to excellence. Our expertise in gene editing and cell line development ensures that our customers receive superior tools for advancing their research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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