Gene: NEK11
Official Full Name: NIMA related kinase 11provided by HGNC
Gene Summary: This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15775 | NEK11 Knockout cell line (HCT 116) | Human | NEK11 | 1:2~1:4 | Negative | Online Inquiry |
KO15776 | NEK11 Knockout cell line (HEK293) | Human | NEK11 | 1:3~1:6 | Negative | Online Inquiry |
KO15777 | NEK11 Knockout cell line (A549) | Human | NEK11 | 1:3~1:4 | Negative | Online Inquiry |
NEK11 Gene Knockout Cell Lines are specially engineered mammalian cell lines that have undergone targeted genetic modification to disrupt the NEK11 gene, a critical component involved in the regulation of cell cycle progression and DNA damage response. By selectively knocking out this gene, researchers can probe its role in various cellular processes and elucidate the mechanisms by which it contributes to cancer proliferation, genomic stability, and potential therapeutic resistance.
These knockout cell lines function by removing the gene's expression, allowing scientists to observe the resulting phenotypic changes compared to wild-type cells. This disruption provides insights into NEK11’s involvement in cellular signaling pathways, the mitotic process, and responses to DNA-damaging agents. With NEK11 implicated in tumorigenesis, studying these cell lines can facilitate the identification of novel therapeutic targets, ultimately advancing cancer research and treatment protocols.
The scientific importance of NEK11 Gene Knockout Cell Lines lies in their versatility and applicability across various research settings, from basic biological studies to targeted pharmacological testing. Unlike conventional cell lines that retain the NEK11 gene, these knockout variants enable a clearer understanding of gene function, thereby accelerating hypothesis-driven research aimed at addressing critical questions in cell biology and oncology.
What sets our NEK11 Gene Knockout Cell Lines apart from alternatives on the market is their reliability and reproducibility. Each line comes with stringent validation testing, ensuring that researchers obtain consistent results, which is crucial for the integrity of their experiments. Additionally, our cell lines are compatible with a wide array of assay formats, including drug sensitivity testing and gene reconstitution studies, making them adaptable for various experimental designs.
For researchers and clinicians investigating the molecular underpinnings of cancer or seeking to develop targeted therapies, NEK11 Gene Knockout Cell Lines provide an invaluable resource to further their objectives. Their targeted approach allows for profound insights into gene-specific functions, ultimately guiding the development of innovative strategies in precision medicine.
At our company, we specialize in providing high-quality biological products tailored to the needs of the research community. With a commitment to scientific excellence and a thorough understanding of cellular biology, we ensure that our offerings empower researchers to achieve their scientific goals effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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