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NASP Knockout Cell Lines

Gene: NASP

Official Full Name: nuclear autoantigenic sperm proteinprovided by HGNC

Gene Summary: This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36469 NASP Knockout cell line (HeLa) Human NASP 1:3~1:6 Negative Online Inquiry
KO36470 NASP Knockout cell line (HCT 116) Human NASP 1:2~1:4 Negative Online Inquiry
KO36471 NASP Knockout cell line (HEK293) Human NASP 1:3~1:6 Negative Online Inquiry
KO36472 NASP Knockout cell line (A549) Human NASP 1:3~1:4 Negative Online Inquiry

Background

NASP Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the Nuclear Autoantigenic Sperm Protein (NASP) gene. These cell lines are invaluable tools for researchers aiming to elucidate the physiological roles and molecular pathways influenced by NASP, a protein implicated in various cellular processes, including chromatin remodeling and spermatogenesis. By employing techniques such as CRISPR-Cas9 or RNA interference, these knockout cell lines enable the study of NASP's functional contributions in vitro, providing a clear model to dissect gene function in health and disease.

The key function of NASP expression is its involvement in histone supply during replication and its role in cellular stress response. By studying NASP knockout cell lines, researchers can gain insights into how the absence of this protein alters gene expression, chromatin structure, and cellular behavior, paving the way for a deeper understanding of its implications in cancer and reproductive biology. These investigations have significant scientific importance, as they open avenues for developing novel therapeutic strategies targeting NASP-related pathways.

What sets NASP Gene Knockout Cell Lines apart from alternative models is their precision and reliability in gene editing, allowing for reproducible and consistent results. Unlike traditional methods that might present variability, these knockout lines maintain a stable genetic background, essential for high-quality experimental outcomes. Furthermore, they come with extensive characterization to ensure the absence of NASP expression and allow for straightforward experimental designs for both basic and applied research.

The value of NASP Gene Knockout Cell Lines extends to researchers and clinicians alike, providing a robust platform to explore NASP's roles and develop interventions for diseases associated with its dysregulation. By facilitating a clearer understanding of gene-disease relationships, these cell lines support advancements in precision medicine.

Our company prides itself on its expertise in genetic engineering and cell line development, ensuring that we provide researchers with cutting-edge tools essential for driving scientific discovery. Trust in our NASP Gene Knockout Cell Lines to enhance your research and clinical insights.

Please note that all services are for research use only. Not intended for any clinical use.

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