Gene: NACC1
Official Full Name: nucleus accumbens associated 1provided by HGNC
Gene Summary: This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30881 | NACC1 Knockout cell line (HeLa) | Human | NACC1 | 1:3~1:6 | Negative | Online Inquiry |
KO30882 | NACC1 Knockout cell line (HCT 116) | Human | NACC1 | 1:2~1:4 | Negative | Online Inquiry |
KO30883 | NACC1 Knockout cell line (HEK293) | Human | NACC1 | 1:3~1:6 | Negative | Online Inquiry |
KO30884 | NACC1 Knockout cell line (A549) | Human | NACC1 | 1:3~1:4 | Negative | Online Inquiry |
NACC1 Gene Knockout Cell Lines are specialized cellular models developed to facilitate the study of the NACC1 gene, which encodes a nuclear protein implicated in various biological processes including transcriptional regulation and cell growth. These engineered cell lines are designed using CRISPR-Cas9 technology to induce a targeted deletion or disruption in the NACC1 gene, allowing researchers to investigate its functional role in cellular signaling pathways and disease mechanisms.
The primary function of these knockout cell lines lies in their ability to provide a controlled environment for examining the consequences of NACC1 gene ablation. By comparing these knockout lines with wild-type counterparts, scientists can uncover the gene's involvement in oncogenic processes, metabolic regulation, and responses to therapeutic agents. This is particularly significant for cancer research, where NACC1 has been implicated in tumor progression and metastasis.
In clinical and research settings, the NACC1 Gene Knockout Cell Lines serve as powerful tools for drug screening, mechanistic studies, and biomarker discovery. Their application can extend to understanding resistance mechanisms in cancer therapies, thus aiding in the development of more effective treatment strategies.
What sets these cell lines apart from other available models is their specificity and high precision in gene editing, providing unparalleled reliability in experimental results. The use of CRISPR-Cas9 not only offers a rapid and efficient method for gene knockout but also reduces off-target effects, enhancing the validity of findings derived from experiments.
Researchers and clinicians stand to gain substantial value from utilizing NACC1 Gene Knockout Cell Lines. Their ability to elucidate complex biological interactions can lead to breakthroughs in therapeutic development and diagnostic advancements, ultimately contributing to enhanced patient care.
Our company boasts a robust portfolio of cutting-edge tools, including these knockout cell lines, developed by experts in the field of molecular biology and genetics. We are committed to advancing scientific discovery by providing high-quality biological products that support innovative research and empower the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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