Gene: NAB2
Official Full Name: NGFI-A binding protein 2provided by HGNC
Gene Summary: This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36480 | NAB2 Knockout cell line (HeLa) | Human | NAB2 | 1:3~1:6 | Negative | Online Inquiry |
KO36481 | NAB2 Knockout cell line (HCT 116) | Human | NAB2 | 1:2~1:4 | Negative | Online Inquiry |
KO36482 | NAB2 Knockout cell line (HEK293) | Human | NAB2 | 1:3~1:6 | Negative | Online Inquiry |
KO36483 | NAB2 Knockout cell line (A549) | Human | NAB2 | 1:3~1:4 | Negative | Online Inquiry |
NAB2 Gene Knockout Cell Lines are specialized laboratory models engineered to lack the expression of the NAB2 gene, which is crucial for studying the gene's functional roles in cellular processes and disease mechanisms. Designed for research applications, these cell lines offer a streamlined approach to investigate the implications of NAB2 deficiency in developmental biology, cancer research, and other related fields.
The key function of NAB2 Gene Knockout Cell Lines lies in their ability to provide insights into the pathways regulated by NAB2, a transcriptional repressor implicated in various cellular responses and oncogenic processes. Researchers can utilize these cell lines to observe alterations in gene expression, signaling pathways, and cellular behavior, thus elucidating the contribution of NAB2 to physiological and pathological states.
The scientific importance of NAB2 Gene Knockout Cell Lines extends to their application in elucidating the role of NAB2 in disease models, particularly in cancers where gene regulation is compromised. These cell lines allow for a robust platform to test therapeutic interventions, screen for drug candidates, and explore molecular interactions that may be disrupted in NAB2-deficient states, thereby bridging bench research with potential clinical applications.
What sets NAB2 Gene Knockout Cell Lines apart from alternative models is their precise genetic modification method that ensures a complete knockout, resulting in clear phenotypic and genotypic characterization. Derived from a variety of cell types, these lines offer flexibility and specificity, catering to diverse experimental needs while maintaining a high standard of reproducibility and reliability.
For researchers, clinicians, and pharmaceutical developers, NAB2 Gene Knockout Cell Lines represent a valuable asset in the quest for understanding complex biological systems and developing targeted therapies. Their ability to simplify experimental designs while providing relevant biological insights makes them indispensable in modern molecular biology studies.
As a trusted leader in the field of biological products, our company is dedicated to delivering high-quality research tools such as NAB2 Gene Knockout Cell Lines, backed by rigorous scientific validation and customer support to empower researchers in their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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