Gene: N4BP2
Official Full Name: NEDD4 binding protein 2provided by HGNC
Gene Summary: This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15930 | N4BP2 Knockout cell line (HeLa) | Human | N4BP2 | 1:3~1:6 | Negative | Online Inquiry |
KO15931 | N4BP2 Knockout cell line (HCT 116) | Human | N4BP2 | 1:2~1:4 | Negative | Online Inquiry |
KO15932 | N4BP2 Knockout cell line (HEK293) | Human | N4BP2 | 1:3~1:6 | Negative | Online Inquiry |
KO15933 | N4BP2 Knockout cell line (A549) | Human | N4BP2 | 1:3~1:4 | Negative | Online Inquiry |
N4BP2 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the N4BP2 gene's role in various biological processes and diseases. This product involves the targeted disruption of the N4BP2 gene, resulting in cell lines that lack functional N4BP2 protein. The creation of these knockout models employs advanced genome editing technologies, such as CRISPR-Cas9, ensuring precise modifications within the genomic structure. Researchers can utilize these cell lines to investigate the biological implications of N4BP2 in cellular signaling pathways, metabolic processes, and its potential involvement in oncogenesis.
The key functions of N4BP2 knockout cell lines lie in their ability to serve as a tool for elucidating the gene's contribution to cellular homeostasis and disease mechanisms. By comparing the knockout lines to their wild-type counterparts, researchers can identify phenotypic changes, assess gene interactions, and explore therapeutic targets. This product holds significant scientific importance in both basic research and clinical studies, offering insights into cellular functions that may inform drug development and therapeutic interventions.
One of the distinct advantages of N4BP2 Gene Knockout Cell Lines is their high specificity and reliability compared to traditional knockout methods, which may introduce off-target effects or incomplete gene disruption. Additionally, these cell lines come with comprehensive documentation, including characterization data, ensuring reproducibility and robust experimental outcomes.
For researchers and clinicians, the N4BP2 knockout models provide invaluable resources in understanding disease mechanisms, enabling the exploration of new therapeutic strategies. By illuminating the role of N4BP2, these cell lines pave the way for advancements in targeted therapies and personalized medicine approaches.
Our company specializes in the development and provision of high-quality biological research tools, bolstered by a team of experts committed to supporting the scientific community with innovative solutions. Trust in N4BP2 Gene Knockout Cell Lines to enhance the precision and efficacy of your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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