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MTPN Knockout Cell Lines

Gene: MTPN

Official Full Name: myotrophinprovided by HGNC

Gene Summary: The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26368 MTPN Knockout cell line (HeLa) Human MTPN 1:3~1:6 Negative Online Inquiry
KO26369 MTPN Knockout cell line (HCT 116) Human MTPN 1:2~1:4 Negative Online Inquiry
KO26370 MTPN Knockout cell line (HEK293) Human MTPN 1:3~1:6 Negative Online Inquiry
KO26371 MTPN Knockout cell line (A549) Human MTPN 1:3~1:4 Negative Online Inquiry

Background

MTPN Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to facilitate in-depth studies of the MTPN gene's function and its role in various biological processes. These cell lines are created using CRISPR/Cas9 technology, which allows for precise and efficient deletion of the MTPN gene, resulting in a knockout phenotype. This enables researchers to investigate the downstream effects of the MTPN gene's absence on cellular pathways, signaling mechanisms, and metabolic processes, enhancing our understanding of its biological significance.

The key function of MTPN Gene Knockout Cell Lines lies in their ability to serve as essential tools for elucidating gene function and gene interactions. By observing the phenotypic changes associated with the knockout, researchers can gain insights into MTPN's role in cellular functions such as proliferation, differentiation, and apoptosis. Furthermore, these cellular models are invaluable in drug discovery, allowing for the identification of novel therapeutic targets and the evaluation of potential treatments in a controlled environment.

In terms of scientific importance, MTPN Gene Knockout Cell Lines have significant applications in both basic research and clinical settings. They can be employed to study various diseases where MTPN may be implicated, such as cancer, metabolic disorders, and other dysregulatory conditions. This positions them as a critical asset for teams focused on understanding pathophysiological mechanisms and developing innovative approaches to treatment.

Compared to traditional cell lines or non-targeted knockout models, MTPN Gene Knockout Cell Lines offer enhanced specificity and reproducibility. The precise gene editing ensures that the observed effects are directly attributable to the absence of the MTPN gene without off-target effects that can confound experimental results. Moreover, our product is backed by rigorous validation studies demonstrating consistent performance, delivering reliability that is paramount in research.

For researchers, clinicians, and biotechnology companies, the MTPN Gene Knockout Cell Lines represent a powerful asset for advancing scientific knowledge and facilitating the development of targeted therapies. Our commitment to quality and innovation, combined with extensive expertise in genomics and cell biology, positions us as a trusted partner in the life sciences arena, dedicated to empowering your research initiatives with leading-edge biological products.

Please note that all services are for research use only. Not intended for any clinical use.

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