Gene: MSX1
Official Full Name: msh homeobox 1provided by HGNC
Gene Summary: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03654 | MSX1 Knockout cell line (HeLa) | Human | MSX1 | 1:3~1:6 | Negative | Online Inquiry |
KO03655 | MSX1 Knockout cell line (HCT 116) | Human | MSX1 | 1:2~1:4 | Negative | Online Inquiry |
KO03656 | MSX1 Knockout cell line (HEK293) | Human | MSX1 | 1:3~1:6 | Negative | Online Inquiry |
KO03657 | MSX1 Knockout cell line (A549) | Human | MSX1 | 1:3~1:4 | Negative | Online Inquiry |
MSX1 Gene Knockout Cell Lines are advanced human-derived cell lines specifically engineered to lack the MSX1 gene, a crucial component in various developmental processes and gene regulatory networks. Through CRISPR/Cas9 gene-editing technology, these cell lines provide a robust tool for exploring the biological implications of MSX1 absence, thereby elucidating its roles in tissue development, stem cell differentiation, and disease pathology, particularly in the context of craniofacial malformations and neurogenesis.
The primary function of the MSX1 Gene Knockout Cell Lines is to serve as a pivotal model for dissecting the gene's contributions to cellular mechanisms and signaling pathways. By examining these knockout cells, researchers can delineate the influence of MSX1 on transcriptional regulation, cellular morphology, proliferation, and apoptosis. Additionally, their application extends into drug discovery and the evaluation of therapeutic interventions targeting MSX1-related disorders. The ability to manipulate these cell lines enables innovative approaches to therapeutic development and personalized medicine.
The scientific importance of these cell lines cannot be overstated; they are essential for advancing our understanding of developmental biology and genetic disorders. Compared to alternative models, such as wild-type cell lines or animal models, the MSX1 Gene Knockout Cell Lines provide more precise insights due to the specific elimination of the very gene of interest. This specificity reduces the background noise present when analyzing genetic mutations, yielding more reliable and reproducible results.
For researchers and clinicians, the MSX1 Gene Knockout Cell Lines offer unparalleled value. By integrating these cell lines into your investigations, you can accelerate the pace of discovery in fields such as developmental biology, genetic epidemiology, and regenerative medicine. With our comprehensive support and expertise, we ensure that you have not only a robust research tool but also a partner committed to advancing your scientific endeavors.
Our company prides itself on delivering high-quality biological products backed by years of research and innovation. With a strong foundation in genetic engineering and cellular biology, we are dedicated to providing researchers and clinicians with the essential tools for groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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