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MRPS36 Knockout Cell Lines

Gene: MRPS36

Official Full Name: alpha-ketoglutarate dehydrogenase subunit 4provided by HGNC

Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23229 MRPS36 Knockout cell line (HeLa) Human MRPS36 1:3~1:6 Negative Online Inquiry
KO23230 MRPS36 Knockout cell line (HCT 116) Human MRPS36 1:2~1:4 Negative Online Inquiry
KO23231 MRPS36 Knockout cell line (HEK293) Human MRPS36 1:3~1:6 Negative Online Inquiry
KO23232 MRPS36 Knockout cell line (A549) Human MRPS36 1:3~1:4 Negative Online Inquiry

Background

MRPS36 Gene Knockout Cell Lines are genetically modified cell lines that have been developed to specifically disrupt the MRPS36 gene, which encodes a mitochondrial ribosomal protein critical for mitochondrial protein synthesis. These knockout cell lines serve as valuable tools for researchers seeking to study the gene's role in cellular physiology, mitochondrial function, and related metabolic pathways. By providing a model system that lacks functional MRPS36, researchers can assess the impacts of this gene’s absence on various cellular processes, elucidating its involvement in mitochondrial biogenesis, energy metabolism, and potential links to diseases.

The key mechanism of action lies in the targeted disruption of the MRPS36 gene, achieved through cutting-edge CRISPR-Cas9 technology. This method ensures high specificity and efficiency in generating knockout models, allowing precise control over genetic variables. By analyzing these cell lines in different experimental contexts, researchers can explore the downstream effects of MRPS36 loss, advancing our understanding of mitochondrial disorders and their pathophysiology.

The scientific importance of MRPS36 Gene Knockout Cell Lines cannot be overstated; they hold potential applications in drug discovery, disease modeling, and therapeutic development. Researchers can utilize these models to test the efficacy and safety of novel compounds, particularly those aimed at restoring mitochondrial function or treating mitochondrial diseases.

One of the distinct advantages of our MRPS36 knockout cell lines is their easily adaptable format that fits into various culture conditions, which streamlines integration into existing workflows. Additionally, our rigorous validation process ensures high-quality and reproducible results, setting this product apart from competing offerings that may lack stringent quality assessments.

For researchers and clinicians, leveraging MRPS36 gene knockout cell lines opens up opportunities for transformative discoveries in cellular and molecular biology. Their specialized utility enhances research productivity and supports the translation of findings into clinical applications.

Our company prides itself on a commitment to excellence in genetic engineering and molecular biology products, ensuring that our offerings are both precise and innovative. With extensive expertise in the development of knockout models, we are dedicated to supporting scientific advancements through high-quality biological research tools.

Please note that all services are for research use only. Not intended for any clinical use.

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