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MRPL41 Knockout Cell Lines

Gene: MRPL41

Official Full Name: mitochondrial ribosomal protein L41provided by HGNC

Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16047 MRPL41 Knockout cell line (HeLa) Human MRPL41 1:3~1:6 Negative Online Inquiry
KO16048 MRPL41 Knockout cell line (HCT 116) Human MRPL41 1:2~1:4 Negative Online Inquiry
KO16049 MRPL41 Knockout cell line (HEK293) Human MRPL41 1:3~1:6 Negative Online Inquiry

Background

MRPL41 Gene Knockout Cell Lines are specialized cellular models engineered to have the MRPL41 gene, which encodes a mitochondrial ribosomal protein, disrupted or completely knocked out. This critical approach enables researchers to investigate the gene's role in mitochondrial function and its contribution to various metabolic processes and diseases. By utilizing CRISPR-Cas9 or other gene-editing technologies, these cell lines facilitate a clearer understanding of the molecular pathways influenced by MRPL41, providing insights into its potential implications in conditions such as mitochondrial diseases, cancer, and aging.

The key mechanism underpinning MRPL41 Gene Knockout Cell Lines involves the targeted alteration of the gene locus. By disrupting the MRPL41 gene, the resultant cell lines exhibit varying degrees of mitochondrial dysfunction, allowing researchers to explore changes in cellular metabolism, stress responses, and apoptosis. This is particularly valuable in dissecting the implications of MRPL41 in mitochondrial protein synthesis and the broader effects on cellular homeostasis.

Scientifically, these cell lines are indispensable tools in both research and clinical settings. They not only contribute to a better understanding of mitochondrial biology but also aid in drug discovery efforts by serving as models to screen compounds that may ameliorate mitochondrial dysfunction. The precise modulation of gene expression patterns through knockout technology provides unparalleled opportunities to design experiments that elucidate cellular responses under different pathological conditions.

One of the distinct advantages of using MRPL41 Gene Knockout Cell Lines lies in their specificity and reproducibility. Unlike general mitochondrial inhibitors, these cell lines offer a targeted approach to studying the direct consequences of MRPL41 loss, thus minimizing off-target effects that may confound results. Additionally, the availability of well-characterized cell lines accelerates the experimental process, providing researchers with reliable models that can be easily replicated across laboratories.

For researchers and clinicians focused on mitochondrial studies, the MRPL41 Gene Knockout Cell Lines represent a critical advancement in genetic research, enabling a deeper exploration of the complexities of mitochondrial function. Their application has the potential to lead to significant breakthroughs in understanding various diseases linked to mitochondrial dysfunction and developing innovative therapeutic strategies.

Our company is dedicated to advancing biomedical research through high-quality biological products. With a commitment to innovation and scientific rigor, we provide a range of expertly developed models and tools that enhance research methodologies and support the scientific community in pushing the boundaries of knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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