Gene: MRPL1
Official Full Name: mitochondrial ribosomal protein L1provided by HGNC
Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16056 | MRPL1 Knockout cell line (HeLa) | Human | MRPL1 | 1:3~1:6 | Negative | Online Inquiry |
KO16057 | MRPL1 Knockout cell line (HCT 116) | Human | MRPL1 | 1:2~1:4 | Negative | Online Inquiry |
KO16058 | MRPL1 Knockout cell line (HEK293) | Human | MRPL1 | 1:3~1:6 | Negative | Online Inquiry |
KO16059 | MRPL1 Knockout cell line (A549) | Human | MRPL1 | 1:3~1:4 | Negative | Online Inquiry |
MRPL1 Gene Knockout Cell Lines are engineered cellular models specifically designed to investigate the functional role of the MRPL1 gene, which encodes a critical component of mitochondrial ribosomal protein L1. These cell lines have been created through homologous recombination techniques that disrupt the MRPL1 gene, effectively knocking it out, and thus enabling researchers to study the consequences of its absence on cellular metabolism and mitochondrial function.
The primary function of MRPL1 is to facilitate mitochondrial protein synthesis, playing a pivotal role in the formation of the mitochondrial ribosome. By utilizing MRPL1 Gene Knockout Cell Lines, researchers can delve into the underlying mechanisms by which mitochondrial defects can lead to various metabolic disorders and mitochondrial diseases. Additionally, these knockout models help elucidate the role of MRPL1 in the broader context of cellular energy production and the associated pathways that drive cellular homeostasis.
From a scientific perspective, the applications of these cell lines are manifold, impacting both basic research and clinical studies. They offer essential insights into the implications of MRPL1 dysfunction in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, thereby aiding the development of targeted therapeutic strategies. Moreover, they provide a robust platform for pharmaceutical screening, toxicology assays, and genetic research where the understanding of mitochondrial dynamics is crucial.
What sets our MRPL1 Gene Knockout Cell Lines apart from alternative products is their high specificity and validation. Each line undergoes rigorous characterization, ensuring that its genomic integrity and functional behaviors are meticulously analyzed. This level of precision enhances reproducibility and reliability in experimental outcomes.
For researchers and clinicians, these cell lines represent a valuable tool that not only complements existing methodologies but also opens new avenues for exploration in mitochondrial research. By addressing critical gaps in understanding mitochondrial biology, these knockout cell lines are instrumental in translating scientific discoveries into clinical applications.
Our company prides itself on its commitment to advancing the frontiers of biological research through innovative and high-quality products. With extensive experience in the field of genetics and cellular biology, we are dedicated to providing research tools that empower scientists to achieve groundbreaking results.
Please note that all services are for research use only. Not intended for any clinical use.
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