Gene: MRAS
Official Full Name: muscle RAS oncogene homologprovided by HGNC
Gene Summary: This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10605 | MRAS Knockout cell line (HeLa) | Human | MRAS | 1:3~1:6 | Negative | Online Inquiry |
KO10606 | MRAS Knockout cell line (HCT 116) | Human | MRAS | 1:2~1:4 | Negative | Online Inquiry |
KO10607 | MRAS Knockout cell line (HEK293) | Human | MRAS | 1:3~1:6 | Negative | Online Inquiry |
KO10608 | MRAS Knockout cell line (A549) | Human | MRAS | 1:3~1:4 | Negative | Online Inquiry |
MRAS Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the MRAS gene, a crucial member of the RAS family of small GTPases. This gene plays a significant role in various cellular processes, including growth, survival, and differentiation. By employing CRISPR/Cas9 gene editing technology, these cell lines provide a powerful tool for studying the specific contributions of MRAS in signal transduction pathways and its implications in oncogenesis and other diseases.
The primary function of MRAS Gene Knockout Cell Lines is to enable researchers to investigate the cellular and molecular mechanisms underlying the loss of MRAS function. The absence of MRAS allows for the dissection of its physiological roles, providing insights into alternate signaling routes that may compensate for its loss and identifying downstream targets influenced by MRAS activity. This information is vital for advancing our understanding of RAS-related pathways, particularly in cancer biology, where aberrant RAS signaling is commonly implicated.
The scientific importance of MRAS Gene Knockout Cell Lines extends to various research and clinical applications. These cell lines are indispensable for drug screening and therapeutic development, particularly in designing personalized treatment regimens for cancers driven by RAS mutations. Their utility in preclinical studies enables clinicians to explore potential pathways for intervention, ultimately leading to more targeted therapies.
One of the unique selling points of our MRAS Gene Knockout Cell Lines is that they are rigorously validated for off-target effects and maintain high levels of stability and reproducibility across multiple passages, offering researchers confidence in their findings. Compared to other gene knockout options, our product stands out due to the careful characterization and optimization of the cell lines, which ensures their applicability in a wide range of experimental setups.
For researchers and clinicians invested in cancer biology and drug development, MRAS Gene Knockout Cell Lines are invaluable resources that foster understanding of complex biological networks and aid in the identification of novel therapeutic targets. Our company prides itself on its extensive expertise in developing high-quality biological products, ensuring that our customers receive reliable tools that can significantly enhance their research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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