Gene: MPP7
Official Full Name: MAGUK p55 scaffold protein 7provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24319 | MPP7 Knockout cell line (HeLa) | Human | MPP7 | 1:3~1:6 | Negative | Online Inquiry |
KO24320 | MPP7 Knockout cell line (HCT 116) | Human | MPP7 | 1:2~1:4 | Negative | Online Inquiry |
KO24321 | MPP7 Knockout cell line (HEK293) | Human | MPP7 | 1:3~1:6 | Negative | Online Inquiry |
MPP7 Gene Knockout Cell Lines are specialized biological tools designed to facilitate the study of MPP7 (Magneto-Respiratory Protecting Protein 7), a gene known to play a critical role in various cellular processes, including cell signaling, apoptosis, and the maintenance of cellular architecture. These knockout cell lines have been engineered to disrupt the MPP7 gene, allowing researchers to investigate the resultant phenotypic changes and gain insights into its biological functions.
The functioning mechanism of MPP7 Gene Knockout Cell Lines revolves around the targeted deletion of the MPP7 gene using CRISPR-Cas9 technology. This gene-editing method introduces a double-strand break in the DNA, which leads to the non-homologous end joining, effectively rendering the MPP7 gene inactive. By studying the knockout model, researchers can observe alterations in cellular behavior, interactions with other proteins, and effects on signal transduction pathways.
The scientific significance of these cell lines extends across multiple research domains, particularly in cancer biology, developmental biology, and neurobiology. Understanding the role of MPP7 in these contexts can illuminate its potential impact on human diseases, thereby aiding in the development of targeted therapeutic strategies. In clinical settings, these knockout models serve as valuable systems for drug screening and can contribute to biomarker discovery, ultimately improving patient outcomes.
What sets MPP7 Gene Knockout Cell Lines apart from alternative models is their high specificity and fidelity in gene disruption, coupled with the ease of use that CRISPR technology provides. These lines allow for rapid generation and validation, minimizing the time and resources needed for experimental workflows. Furthermore, our cell lines are developed under stringent quality control measures, ensuring the reliability and reproducibility of results.
Researchers and clinicians alike will find immense value in utilizing MPP7 Gene Knockout Cell Lines to gain deeper biological insight and accelerate discoveries in their respective fields. Our commitment to excellence in developing high-quality biological products is rooted in extensive expertise and innovation, short-circuiting the pathway between inquiry and application.
Please note that all services are for research use only. Not intended for any clinical use.
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