Gene: MPI
Official Full Name: mannose phosphate isomeraseprovided by HGNC
Gene Summary: Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36580 | MPI Knockout cell line (HeLa) | Human | MPI | 1:3~1:6 | Negative | Online Inquiry |
KO36581 | MPI Knockout cell line (HCT 116) | Human | MPI | 1:2~1:4 | Negative | Online Inquiry |
KO36582 | MPI Knockout cell line (HEK293) | Human | MPI | 1:3~1:6 | Negative | Online Inquiry |
KO36583 | MPI Knockout cell line (A549) | Human | MPI | 1:3~1:4 | Negative | Online Inquiry |
MPI Gene Knockout Cell Lines represent a cutting-edge approach in genetic research, providing a vital tool for studying gene function and elucidating cellular mechanisms underlying various biological processes. These cell lines are genetically engineered to lack specific target genes, allowing researchers to observe the resultant phenotypic changes, assess gene role in metabolic pathways, and explore therapeutic targets for diseases.
The key function of MPI Gene Knockout Cell Lines lies in their precise gene editing, often utilizing CRISPR/Cas9 technology or similar methodologies to disrupt gene expression. This targeted approach ensures high specificity, allowing researchers to dissect the roles of individual genes within complex regulatory networks. By comparing knockout lines to their wild-type counterparts, scientists can glean insights into gene interactions, signaling pathways, and the phenotypic consequences of gene deletion, significantly contributing to the understanding of genetic contributions to disease.
The scientific importance of these cell lines is underscored by their diverse applications, from fundamental research exploring gene function to translational studies focused on drug discovery and development. They have become indispensable in oncology, immunology, and developmental biology, opening avenues for personalized medicine and novel therapeutic interventions.
Compared to traditional knockdown systems, such as RNA interference, MPI Gene Knockout Cell Lines provide stable, heritable changes that allow for long-term experiments and more reproducible results. This reliability makes them a superior choice when compared to transient methods, where results can vary with each experiment and cell division cycle.
Researchers and clinicians alike find immense value in utilizing MPI Gene Knockout Cell Lines due to their robust, validated performance and ease of incorporation into existing workflows. The ability to generate precise gene deletions empowers scientists to accelerate discoveries, ultimately translating to faster development of therapeutic strategies for complex diseases.
Our company prides itself on its commitment to quality and innovation in biological products, leveraging extensive expertise in genetic engineering to provide researchers with reliable tools that drive advancements in scientific knowledge and clinical applications. By choosing MPI Gene Knockout Cell Lines, users benefit from our dedication to excellence in research and our ongoing support tailored to enhance their study outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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