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MMRN2 Knockout Cell Lines

Gene: MMRN2

Official Full Name: multimerin 2provided by HGNC

Gene Summary: This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16134 MMRN2 Knockout cell line (HeLa) Human MMRN2 1:3~1:6 Negative Online Inquiry
KO16135 MMRN2 Knockout cell line (HCT 116) Human MMRN2 1:2~1:4 Negative Online Inquiry

Background

MMRN2 Gene Knockout Cell Lines represent a pivotal resource in molecular biology, designed for the functional study of the MMRN2 gene, which plays a crucial role in extracellular matrix organization and cellular adhesion. By employing advanced CRISPR/Cas9 technology, these cell lines are specifically engineered to exhibit a complete knockout of the MMRN2 gene, allowing researchers to investigate the consequences of gene loss on various cellular processes.

The primary function of the MMRN2 Gene Knockout Cell Lines is to facilitate in-depth analyses of the gene's biological role. These cell lines provide a unique platform to explore the underlying mechanisms of pathology related to MMRN2, including its involvement in cardiovascular diseases, connective tissue disorders, and cancer metastasis. By examining the cellular responses and phenotypic variations induced by the knockout, researchers can elucidate molecular pathways and identify potential therapeutic targets.

In terms of scientific importance, these knockout cell lines have far-reaching applications in both basic research and clinical settings. They can be utilized in drug discovery processes to assess the efficacy of therapeutic compounds that may interact with pathways modulated by MMRN2. Furthermore, they serve as invaluable tools for gene editing studies, protein interactions, and functional validation of genetic variants associated with disease.

Compared to alternative models, MMRN2 Gene Knockout Cell Lines offer unparalleled specificity and control over gene expression, ensuring that the observed effects can be reliably attributed to the deletion of MMRN2. This specificity minimizes off-target effects commonly associated with less precise gene-editing techniques, thereby enhancing experimental reproducibility.

Researchers and clinicians will find MMRN2 Gene Knockout Cell Lines valuable for advancing their understanding of gene function in disease contexts, enabling the design of innovative therapeutic strategies. The flexible application of these cell lines in diverse experimental setups underscores their significance in the current landscape of biomedical research.

At [Company Name], we are committed to advancing scientific discovery by providing high-quality biological products, including our MMRN2 Gene Knockout Cell Lines. Our expertise in genetic engineering and a deep understanding of cellular biology ensure that our offerings meet the rigorous demands of researchers worldwide.

Please note that all services are for research use only. Not intended for any clinical use.

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