Home / MLXIPL Knockout Cell Lines

MLXIPL Knockout Cell Lines

Gene: MLXIPL

Official Full Name: MLX interacting protein likeprovided by HGNC

Gene Summary: This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06261 MLXIPL Knockout cell line (HeLa) Human MLXIPL 1:3~1:6 Negative Online Inquiry
KO06262 MLXIPL Knockout cell line (HCT 116) Human MLXIPL 1:2~1:4 Negative Online Inquiry
KO06263 MLXIPL Knockout cell line (HEK293) Human MLXIPL 1:3~1:6 Negative Online Inquiry
KO06264 MLXIPL Knockout cell line (A549) Human MLXIPL 1:3~1:4 Negative Online Inquiry

Background

MLXIPL Gene Knockout Cell Lines are specifically engineered cellular models that feature targeted deletions of the MLXIPL gene, which encodes a transcription factor involved in the regulation of metabolic pathways. These cell lines serve as invaluable tools for researchers investigating the implications of MLXIPL in cellular metabolism, lipid homeostasis, and energy regulation. By utilizing CRISPR/Cas9 gene editing technology, MLXIPL Gene Knockout Cell Lines enable precise alterations in genomic DNA, allowing scientists to dissect the functional roles of this gene and its potential connections to metabolic disorders.

The primary function of these knockout cell lines is to permit the exploration of the MLXIPL pathway by facilitating the study of the downstream effects of gene depletion in various biological contexts. Researchers can examine alterations in cellular responses to nutrient signals, the regulation of glucose levels, and insulin sensitivity in vitro, offering insights pertinent to conditions such as obesity, diabetes, and cardiovascular diseases. This functional characterization contributes significantly to the understanding of metabolic dysregulation and its associated pathophysiologies.

In terms of scientific application, MLXIPL Gene Knockout Cell Lines are suitable for use in academic research laboratories, pharmaceutical development, and personalized medicine studies. They provide a robust platform for drug screening, targeting pathways modulated by MLXIPL, and assessing the efficacy of therapeutic interventions aimed at metabolic diseases.

Compared to other models, like wild-type or transient knockdown systems, MLXIPL Gene Knockout Cell Lines offer the distinctive advantage of stability and reproducibility, given their permanent genetic modification. These cell lines eliminate variability and allow for longitudinal studies, making them a preferred choice for rigorous scientific investigations.

This product's value to researchers and clinicians lies in its ability to elucidate complex biological mechanisms and drive innovative research efforts related to metabolic health. By employing MLXIPL Gene Knockout Cell Lines, users can gain deeper insights that potentially lead to the development of new treatment strategies.

With a commitment to advancing scientific knowledge through the provision of high-quality biological products, our company combines state-of-the-art gene editing technologies with rigorous quality control to ensure that our products meet the highest research standards.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.