Gene: MKNK2
Official Full Name: MAPK interacting serine/threonine kinase 2provided by HGNC
Gene Summary: This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08294 | MKNK2 Knockout cell line (HeLa) | Human | MKNK2 | 1:3~1:6 | Negative | Online Inquiry |
KO08295 | MKNK2 Knockout cell line (HCT 116) | Human | MKNK2 | 1:2~1:4 | Negative | Online Inquiry |
KO08296 | MKNK2 Knockout cell line (HEK293) | Human | MKNK2 | 1:3~1:6 | Negative | Online Inquiry |
KO08297 | MKNK2 Knockout cell line (A549) | Human | MKNK2 | 1:3~1:4 | Negative | Online Inquiry |
MKNK2 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the expression of the MKNK2 gene, which encodes a protein kinase involved in several cellular processes including cell growth, proliferation, and stress response pathways. The absence of MKNK2 allows for detailed study of its physiological roles and contributions to various diseases, particularly those related to cancer and cellular stress responses.
The mechanism of action of MKNK2 is primarily linked with the regulation of protein synthesis and signal transduction pathways. By inhibiting MKNK2 activity, researchers can evaluate downstream effects on the phosphorylation of eIF4E, an essential factor in the initiation of translation. This knockout model provides a powerful tool for dissecting the impact of MKNK2 on cellular behaviors in both basal and stress-induced conditions.
The scientific importance of MKNK2 Gene Knockout Cell Lines extends to their application in cancer research, where elucidating the role of MKNK2 can unveil novel therapeutic targets. Additionally, these cell lines are invaluable in studying cellular adaptations to stress, potentially leading to breakthroughs in understanding disease mechanisms and developing new treatment strategies.
Compared to alternatives such as conventional wild-type cell lines or less specific knockdown approaches, MKNK2 Gene Knockout Cell Lines offer a precise and unambiguous model that ensures accurate interpretation of results. This specificity enhances reproducibility and reliability in experimental outcomes, making them a superior choice for researchers focused on dissecting the intricate roles of protein kinases.
For researchers, clinicians, or any professionals in the field, the MKNK2 Gene Knockout Cell Lines represent a significant investment in high-quality research tools that can accelerate discoveries and therapeutic innovations. Our company, with its robust expertise in genetic engineering and cell line development, stands committed to providing top-tier biological products that empower the scientific community to push the boundaries of current research.
Please note that all services are for research use only. Not intended for any clinical use.
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