Gene: MICAL1
Official Full Name: microtubule associated monooxygenase, calponin and LIM domain containing 1provided by HGNC
Gene Summary: This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20707 | MICAL1 Knockout cell line (HeLa) | Human | MICAL1 | 1:3~1:6 | Negative | Online Inquiry |
KO20708 | MICAL1 Knockout cell line (HCT 116) | Human | MICAL1 | 1:2~1:4 | Negative | Online Inquiry |
KO20709 | MICAL1 Knockout cell line (HEK293) | Human | MICAL1 | 1:3~1:6 | Negative | Online Inquiry |
KO20710 | MICAL1 Knockout cell line (A549) | Human | MICAL1 | 1:3~1:4 | Negative | Online Inquiry |
MICAL1 Gene Knockout Cell Lines represent a sophisticated tool for investigating the functional dynamics of the MICAL1 gene, a crucial component implicated in various cellular processes, including oxidation-reduction reactions and cytoskeletal organization. These engineered cell lines have been meticulously crafted using CRISPR-Cas9 technology to ensure precise deletion of the MICAL1 gene, providing researchers with an invaluable resource for studying gene function and related biological pathways.
The key mechanism underlying the MICAL1 knockout involves the targeted modification of the gene's sequence, leading to loss of expression. This allows for detailed analyses of phenotypic changes, cellular signaling pathways, and genetic interactions. By employing these knockout cell lines, researchers can elucidate the role of MICAL1 in fundamental processes such as cell motility, differentiation, and neurobiology, significantly advancing our understanding of both healthy and diseased states.
In terms of scientific importance, MICAL1 knockout cell lines are instrumental in cancer research, neurodegenerative studies, and cellular stress responses. Their application extends to drug development, where understanding MICAL1’s role could lead to novel therapeutic strategies. These cell lines also facilitate high-throughput screening, enabling researchers to assess the effects of compounds on cellular functions without the confounding factors introduced by a functioning MICAL1 gene.
What sets MICAL1 Gene Knockout Cell Lines apart from existing alternatives is their validated specificity, reliability, and the comprehensive support materials provided, including detailed protocols and characterization data. This ensures that researchers can achieve reproducible results with confidence. Furthermore, the ease of use and the ability to be tailored for specific experimental conditions make these cell lines particularly attractive for both basic and applied research.
Ultimately, investing in MICAL1 Gene Knockout Cell Lines means empowering researchers and clinicians to unlock new avenues in gene function research and therapeutic discovery. Our company is dedicated to providing high-quality biological products, backed by extensive research and development, ensuring that you receive the tools necessary to advance your scientific inquiries.
Please note that all services are for research use only. Not intended for any clinical use.
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