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MGAT5 Knockout Cell Lines

Gene: MGAT5

Official Full Name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferaseprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04213 MGAT5 Knockout cell line (HeLa) Human MGAT5 1:3~1:6 Negative Online Inquiry
KO04214 MGAT5 Knockout cell line (HCT 116) Human MGAT5 1:2~1:4 Negative Online Inquiry
KO04215 MGAT5 Knockout cell line (HEK293) Human MGAT5 1:3~1:6 Negative Online Inquiry
KO04216 MGAT5 Knockout cell line (A549) Human MGAT5 1:3~1:4 Negative Online Inquiry

Background

MGAT5 Gene Knockout Cell Lines represent a cutting-edge advancement in the field of molecular biology and genetics. These specialized cell lines have been genetically modified to disrupt the MGAT5 gene, which encodes an enzyme critical for N-glycan biogenesis in glycoproteins. By knocking out this gene, researchers can effectively study the role of MGAT5 in various biological processes, including cell adhesion, signaling pathways, and disease mechanisms, particularly in cancer and developmental biology.

The primary mechanism through which these cell lines operate involves the alteration of glycosylation patterns, which significantly influence protein function and stability. The absence of MGAT5 leads to modifications in N-glycans, thus allowing researchers to delineate how these changes affect protein interactions and cellular behavior. This functional insight is crucial for understanding the implications of glycosylation in health and disease, enabling better-targeted therapeutic strategies.

In research and clinical settings, MGAT5 Gene Knockout Cell Lines have vast applications, including but not limited to cancer research, autoimmune studies, and regenerative medicine. They serve as valuable tools for dissecting biochemical pathways and for screening potential drugs that target glycosylation-related pathways.

What sets MGAT5 Gene Knockout Cell Lines apart from traditional cell lines or alternative gene editing techniques is their precision and reliability. These cell lines are extensively characterized, ensuring that researchers can trust their results. Moreover, using knockout models can produce more relevant data, reducing the need for extensive validation that is often required with alternative methods.

For researchers and clinicians looking to deepen their understanding of glycan biology or explore new avenues for therapeutic interventions, MGAT5 Gene Knockout Cell Lines illuminate complex pathways in a comprehensible way. With our extensive expertise in genetic engineering and commitment to advancing biological research, we offer these robust cell lines as part of our comprehensive product portfolio, equipping you with the tools necessary for groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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