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MGAT4A Knockout Cell Lines

Gene: MGAT4A

Official Full Name: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Aprovided by HGNC

Gene Summary: This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30987 MGAT4A Knockout cell line (HCT 116) Human MGAT4A 1:2~1:4 Negative Online Inquiry
KO30988 MGAT4A Knockout cell line (HEK293) Human MGAT4A 1:3~1:6 Negative Online Inquiry
KO30989 MGAT4A Knockout cell line (A549) Human MGAT4A 1:3~1:4 Negative Online Inquiry

Background

MGAT4A Gene Knockout Cell Lines are specially engineered cells that have undergone targeted gene editing to disrupt the expression of the MGAT4A gene, which plays a crucial role in glycosylation processes within cells. This gene is responsible for encoding a glycosyltransferase enzyme involved in the synthesis of complex carbohydrates, which directly influence protein stability, activity, and cellular interactions. The knockout of the MGAT4A gene, therefore, provides researchers with a powerful tool to study the consequences of glycosylation alterations in various biological systems.

The key function of MGAT4A Gene Knockout Cell Lines lies in their ability to facilitate the investigation of glycoprotein modifications and their effects on cellular behavior, such as adhesion, migration, and immune evasion. By altering the glycosylation patterns, researchers can gain insights into disease mechanisms related to cancer, autoimmune disorders, and infectious diseases. The utility of these cell lines extends to drug development, where understanding glycosylation is vital for optimizing therapeutic proteins and monoclonal antibodies.

Unique selling points of MGAT4A Gene Knockout Cell Lines include their specificity and reliability, achieved through advanced CRISPR/Cas9 technology, which allows for precise gene edits with minimal off-target effects. This level of accuracy is often superior to traditional knockout methods. Additionally, the ready-to-use format of these cell lines accelerates experimental timelines, enabling researchers to focus on key investigations rather than the labor-intensive process of creating their own knockout models.

For both researchers and clinicians, the value of MGAT4A Gene Knockout Cell Lines is evident in their potential to advance the understanding of glycosylation-related diseases and to support the development of more effective therapeutic strategies. By providing a robust platform for exploring the functional consequences of MGAT4A deficiency, these cell lines represent an essential resource in the field of glycobiology.

Our company specializes in delivering high-quality biological products for research, utilizing state-of-the-art technologies and a commitment to excellence. This expertise ensures that our MGAT4A Gene Knockout Cell Lines meet the rigorous standards demanded by the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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