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MGAT2 Knockout Cell Lines

Gene: MGAT2

Official Full Name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseprovided by HGNC

Gene Summary: The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06221 MGAT2 Knockout cell line (HeLa) Human MGAT2 1:3~1:6 Negative Online Inquiry
KO06222 MGAT2 Knockout cell line (HCT 116) Human MGAT2 1:2~1:4 Negative Online Inquiry
KO06223 MGAT2 Knockout cell line (HEK293) Human MGAT2 1:3~1:6 Negative Online Inquiry
KO06224 MGAT2 Knockout cell line (A549) Human MGAT2 1:3~1:4 Negative Online Inquiry

Background

MGAT2 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of glycosylation processes, specifically focusing on the role of the MGAT2 gene in N-glycan biosynthesis. This gene encodes an enzyme that catalyzes the formation of complex carbohydrates crucial for various biological functions, including protein folding, stability, and cellular signaling. By targeting and knocking out MGAT2, these cell lines enable researchers to elucidate the impact of altered glycosylation patterns on cellular behavior and pathology.

The primary mechanism by which MGAT2 Gene Knockout Cell Lines operate involves the ablation of the gene responsible for modifying glycan structures on proteins. This disruption allows for the investigation of downstream effects on glycoprotein functionality, thereby providing deeper insights into the pathological roles that aberrant glycosylation plays in diseases such as cancer, inflammation, and genetic disorders. Utilizing these advanced cell lines, researchers can conduct high-throughput studies and screen for therapeutic interventions that target glycosylation pathways.

The scientific importance of MGAT2 Gene Knockout Cell Lines cannot be overstated, as they are essential tools in both fundamental research and clinical applications. They offer unprecedented opportunities to explore the functional consequences of glycosylation changes, yielding insights that may contribute to novel diagnostic markers and targeted therapies. Unlike standard cell lines, these specifically engineered models offer a controlled experimental environment that emphasizes the role of MGAT2, providing clarity that may be absent in other systems.

Unique selling points include enhanced specificity for glycosylation studies, considerable reproducibility in experimental results, and the ability to cross-reference findings with other existing models. The use of MGAT2 Gene Knockout Cell Lines allows for more precise experimental setups, resulting in robust data crucial for understanding disease mechanisms at a biochemical level.

By integrating these cell lines into their research portfolio, scientists and clinicians can advance their investigations with a high degree of confidence in the validity of their findings. Our company specializes in providing high-quality biological models tailored to accelerate research and therapeutic development. With our expertise and commitment to innovation, we aim to support the scientific community in unlocking new frontiers in glycosylation research.

Please note that all services are for research use only. Not intended for any clinical use.

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