Gene: MFNG
Official Full Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by HGNC
Gene Summary: This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene may control Notch signaling in claudin-low breast cancer. [provided by RefSeq, May 2018]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11372 | MFNG Knockout cell line (HCT 116) | Human | MFNG | 1:2~1:4 | Negative | Online Inquiry |
KO11373 | MFNG Knockout cell line (HEK293) | Human | MFNG | 1:3~1:6 | Negative | Online Inquiry |
KO11374 | MFNG Knockout cell line (A549) | Human | MFNG | 1:3~1:4 | Negative | Online Inquiry |
MFNG Gene Knockout Cell Lines are specialized cell line models in which the MFNG gene, known for its role in the Notch signaling pathway and various developmental processes, has been rendered inactive through targeted gene editing techniques. These knockout models are invaluable tools for researchers seeking to explore the functional implications of MFNG in cellular biology, particularly in relation to cell differentiation, proliferation, and signaling pathways.
These cell lines function by utilizing CRISPR/Cas9 technology or similar gene-editing methodologies to precisely disrupt the MFNG gene, thereby allowing for in-depth studies of the gene's contribution to cellular processes and disease mechanisms. Researchers can investigate the resulting phenotypic alterations, assess changes in gene expression profiles, and evaluate any downstream effects on cell signaling, which can provide insights into the molecular underpinnings of various pathologies, including cancers and developmental disorders.
The scientific importance of MFNG Gene Knockout Cell Lines extends to both fundamental research and clinical applications. They serve as crucial models for studying the role of MFNG in context to Notch-related diseases, providing a platform for drug discovery and the development of targeted therapies. Their application in high-throughput screening assays enables researchers to rapidly identify compounds that might reverse or modulate the knockout phenotype, thus accelerating translational research efforts.
Compared to traditional knockdown methods, such as RNA interference, the knockout approach offers a more durable and complete genetic alteration, leading to more reliable results. Moreover, MFNG Gene Knockout Cell Lines are developed under rigorous quality control standards, ensuring high reproducibility and robustness for experimental applications.
For researchers and clinicians, the MFNG Gene Knockout Cell Lines are invaluable assets that facilitate a deeper understanding of genetic functions and disease mechanisms. By providing precise and functional insights into the MFNG gene, these cell lines represent a significant advancement in the study of development and disease.
With a strong commitment to innovation and excellence, our company specializes in providing high-quality biological products, including cell lines and gene-editing tools, to support the scientific community in unraveling complex biological questions. Our expertise ensures that researchers have access to reliable models that drive their work forward.
Please note that all services are for research use only. Not intended for any clinical use.
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