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MEF2A Knockout Cell Lines

Gene: MEF2A

Official Full Name: myocyte enhancer factor 2Aprovided by HGNC

Gene Summary: The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08382 MEF2A Knockout cell line (HeLa) Human MEF2A 1:3~1:6 Negative Online Inquiry
KO08383 MEF2A Knockout cell line (HCT 116) Human MEF2A 1:2~1:4 Negative Online Inquiry
KO08384 MEF2A Knockout cell line (HEK293) Human MEF2A 1:3~1:6 Negative Online Inquiry
KO08385 MEF2A Knockout cell line (A549) Human MEF2A 1:3~1:4 Negative Online Inquiry

Background

MEF2A Gene Knockout Cell Lines are meticulously engineered cellular models that lack the expression of the MEF2A gene, a pivotal transcription factor involved in various cellular processes, including muscle differentiation, memory formation, and apoptosis. These cell lines serve as essential tools for researchers investigating the functional roles of MEF2A in both physiological and pathological contexts. By utilizing the CRISPR-Cas9 or other targeted gene-editing technologies, these knockout cell lines facilitate the study of gene expression pathways and allow for the examination of cellular responses in the absence of MEF2A.

The MEF2A gene is known to regulate multiple downstream genes, influencing key signaling pathways that are vital in developmental biology and disease mechanisms. Researchers can employ these knockout lines to elucidate the impact of MEF2A deficiency on cellular behavior, including proliferation, differentiation, and response to stressors. Additionally, scientists can explore the role of MEF2A in various diseases, such as cancer and neurodegenerative disorders, thereby advancing our understanding of gene function in health and disease.

Compared to conventional methods of gene silencing, such as RNA interference, MEF2A Gene Knockout Cell Lines provide a permanent and stable gene disruption, offering more robust insights into gene function and its associated phenotypic consequences. These cell lines maximize experimental reproducibility and allow for long-term studies that are critical in developmental and translational research.

For researchers and clinicians, the availability of MEF2A Gene Knockout Cell Lines not only accelerates the pace of discovery but also enhances the potential for developing therapeutics targeting MEF2A-related pathways. The value of this product lies in its ability to support ground-breaking research that could lead to enhanced disease understanding and novel treatment strategies.

Built on a firm foundation of expertise in genetic engineering and cellular biology, our company is dedicated to providing top-quality biological products tailored to the needs of the scientific community. By offering reliable and cutting-edge research tools such as the MEF2A Gene Knockout Cell Lines, we aim to empower researchers in their quest for scientific breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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