Gene: MED24
Official Full Name: mediator complex subunit 24provided by HGNC
Gene Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32618 | MED24 Knockout cell line (HeLa) | Human | MED24 | 1:3~1:6 | Negative | Online Inquiry |
KO32619 | MED24 Knockout cell line (HCT 116) | Human | MED24 | 1:2~1:4 | Negative | Online Inquiry |
KO32620 | MED24 Knockout cell line (HEK293) | Human | MED24 | 1:3~1:6 | Negative | Online Inquiry |
KO32621 | MED24 Knockout cell line (A549) | Human | MED24 | 1:3~1:4 | Negative | Online Inquiry |
MED24 Gene Knockout Cell Lines are engineered cellular platforms designed to facilitate the study of gene function and the elucidation of disease mechanisms by enabling targeted genetic modifications. These cell lines have undergone precise genome editing through advanced CRISPR/Cas9 technology, allowing for the specific deletion of the MED24 gene. This targeted approach enables researchers to investigate the roles of MED24 in various biological processes, such as transcriptional regulation, cell proliferation, and response to environmental stimuli.
The key mechanism underlying the MED24 Gene Knockout Cell Lines involves the disruption of the MED24 gene, which is crucial for the formation and function of the Mediator complex, an essential component in the transcriptional regulation pathway. By utilizing these knockout cell lines, scientists can examine the downstream effects of MED24 loss on cellular signaling, gene expression profiles, and overall cell behavior, thus advancing our understanding of how dysregulation of this gene may contribute to pathological conditions.
In terms of scientific importance, MED24 Gene Knockout Cell Lines are invaluable for both basic and translational research. Their applications extend to cancer biology, metabolic disorders, and therapeutic development, providing critical insights into the molecular underpinnings of various diseases. By utilizing these specialized cell lines, researchers can pave the way for innovative therapeutic strategies and personalized medicine approaches.
Compared to conventional gene knockdown approaches, MED24 knockout cell lines offer several distinct advantages. They provide a stable and permanent genetic modification, reducing variability in experimental outcomes and allowing for long-term studies. Additionally, the precision of CRISPR/Cas9 technology ensures high efficiency and specificity, minimizing off-target effects traditionally associated with RNA interference methods.
For researchers and clinicians seeking to deepen their understanding of gene function and its implications in health and disease, MED24 Gene Knockout Cell Lines represent a highly useful tool that facilitates rigorous investigation and experimentation. At [Your Company Name], we are committed to providing high-quality biological products that meet the evolving needs of the scientific community, backed by our extensive expertise in genetic engineering and cell biology.
Please note that all services are for research use only. Not intended for any clinical use.
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