Gene: MED13L
Official Full Name: mediator complex subunit 13Lprovided by HGNC
Gene Summary: The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29329 | MED13L Knockout cell line (HeLa) | Human | MED13L | 1:3~1:6 | Negative | Online Inquiry |
KO29330 | MED13L Knockout cell line (HCT 116) | Human | MED13L | 1:2~1:4 | Negative | Online Inquiry |
KO29331 | MED13L Knockout cell line (HEK293) | Human | MED13L | 1:3~1:6 | Negative | Online Inquiry |
KO29332 | MED13L Knockout cell line (A549) | Human | MED13L | 1:3~1:4 | Negative | Online Inquiry |
MED13L Gene Knockout Cell Lines are specialized biological research tools generated using advanced gene editing technologies, such as CRISPR/Cas9, to inactivate the MED13L gene. These cell lines serve as invaluable models for studying the intricate roles of MED13L, a critical component of the Mediator complex involved in the regulation of gene transcription. By effectively knocking out this gene, researchers are able to elucidate the molecular pathways influenced by MED13L and its implications in various physiological and pathological states.
The primary mechanism of action involves the disruption of MED13L function, leading to alterations in gene expression profiles. This can provide insights into how aberrations in this gene contribute to conditions such as developmental disorders and certain types of cancer. Additionally, these knockout cell lines can be utilized to perform high-throughput screening for potential pharmacological agents or to validate therapeutic targets, bridging laboratory findings to clinical applications.
The scientific significance of MED13L Gene Knockout Cell Lines is underscored by their versatility across numerous research fields, including developmental biology, oncology, and genetics. Compared to conventional cell lines that may not represent the complexity of gene function accurately, these knockout lines offer a distinct advantage by providing a direct understanding of gene action and interaction. Furthermore, researchers can design specific experiments to assess the impact of MED13L disruption, fostering novel discoveries in cellular and molecular biology.
For researchers and clinicians alike, the value of utilizing MED13L Gene Knockout Cell Lines lies in their potential to accelerate breakthroughs while minimizing uncertainty in experimental outcomes. These models help in establishing causal relationships between gene function and disease, ultimately contributing to advancements in precision medicine and targeted therapies.
Our company specializes in providing high-quality biological products with a strong emphasis on innovation and research excellence. With expertise in gene editing and cellular technologies, we are committed to delivering tools that empower the scientific community to advance their discoveries and enhance their understanding of complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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